DMBT1/GP340 Antibody [Alexa Fluor® 350]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 350

DMBT1/GP340 Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant mouse DMBT1
  Trp215-Gly420
  Accession # Q60997
• Specificity: Detects mouse DMBT1 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DMBT1/GP340 Antibody [Alexa Fluor® 350]

• CRP-ductin
• deleted in malignant brain tumors 1 protein
• deleted in malignant brain tumors 1
• DMBT1
• Ebnerin
• FLJ61058
• Glycoprotein 340
• GP340
• gp-340
• GP340muclin
• Hensin
• MGC164738
• Muclin
• SAG
• Salivary agglutinin
• Surfactant pulmonary-associated D-binding protein
• Vomeroglandin

Background

DMBT1 (Deleted in malignant brain tumor-1; also MUCLIN, Hensin, CRP-Ductin, and gp300/350) is a 230‑350 kDa member of the DMBT1 family of molecules. It is expressed by select cell types, including macrophages, intestinal epithelium, and pancreatic acinar cells. DMBT1 is both transmembrane (TM) and secreted, and possesses multiple activities that may be predicated on multimerization. It drives epithelial differentiation, binds Gm⁺ and Gm^- bacteria, and associates with cytoskeletal actin. Mouse DMBT1 is a type I TM glycoprotein 2085 amino acids (aa) in length. Its extracellular region contains eight SRCR repeats (aa 31‑980, plus 1510‑1610), five CUB domains (aa 1023‑1490, plus 1633‑1742), and a ZP segment (aa 1751‑1999). Multiple splice variants exist. There are deletions of aa 584‑733, 397‑534, 593‑731 and, 2032‑2085 (within the TM segment), plus an insertion of 11 aa after Asp29. Over aa 215‑420, mouse DMBT1 shares 75% aa identity with human DMBT1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.