DEC1 Antibody [HRP]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ChIP, ELISA, Flow, ICC/IF, IHC, IP, WB, ChIP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: HRP

DEC1 Antibody [HRP] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Synthetic peptide made to a C-terminal region of human DEC1 (between amino acids 350-412) [UniProt O14503]
• Localization: Nucleus
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BHLHE40
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP)
  • Chromatin Immunoprecipitation Sequencing
  • Chromatin Immunoprecipitation
  • ELISA
  • Flow Cytometry
  • Immunoblotting
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NB100-1800. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.
• Readout System:
  • NovaLume Plus Chemiluminescent Reagent LUM-555

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 26834156).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for DEC1 Antibody [HRP]

• basic helix-loop-helix domain containing, class B, 2
• basic helix-loop-helix family, member e40
• bHLHb2
• bHLHe40
• Class B basic helix-loop-helix protein 2
• class E basic helix-loop-helix protein 40
• DEC1HLHB2
• differentially expressed in chondrocytes 1
• Differentially expressed in chondrocytes protein 1
• differentiated embryo chondrocyte expressed gene 1
• Enhancer-of-split and hairy-related protein 2
• SHARP2
• SHARP-2
• Stimulated by retinoic acid gene 13 protein
• STRA13FLJ99214
• Stra14

Background

Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is an important protein involved in embryonic cell differentiation, proliferation, and apoptosis. It has also recently been shown to be regulated by hypoxia. The loss of DEC1 expression may be an early event in the development of lung cancer, while DEC1 may be up-regulated by hypoxia in other cancers and in more extreme hypoxia it may have a role in cell death.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BHLHE40