Mouse reactivity reported in scientific literature (PMID: 31176039). Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.
peroxisomal multifunctional enzyme type 2,17-beta-HSD IV
peroxisomal multifunctional protein 2,17beta-estradiol dehydrogenase type IV
short chain dehydrogenase/reductase family 8C, member 1,3-alpha
The protein encoded by the HSD17B4 gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathwayfor fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chainand 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidationactivity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present onchromosome 8. (provided by RefSeq)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
We first test this antibody in HEK293T (Human Embryonic Kidney Cells) and N2a (mouse neuroblastoma cell line) cell lysis. Both of them show the positive bands when NBP2-46005 is used. Then we do the IP experiments, the bait is the interacting protein of HSD17B4 coated beads which are incubated with N2a cell lysates, we also set the control which is free of any interacting protein of HSD17B4. It can be detected in the blot that input and bait both show the positive bands of HSD17B4 but not control.
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