DDR1 Antibody

Images

 
Western Blot: DDR1 Antibody [NBP1-33134] - Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE; antibody diluted at 1:5000.
Immunohistochemistry-Paraffin: DDR1 Antibody [NBP1-33134] - Analysis of paraffin-embedded human ovarian cancer, using DDR1 antibody at 1:500 dilution.
Western Blot: DDR1 Antibody [NBP1-33134] - Sample (50 ug of whole cell lysate) A: Mouse brain 7. 5% SDS PAGE; antibody diluted at 1:1000.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Mk, PmSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

DDR1 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human DDR1. The exact sequence is proprietary.
Localization
Isoform 1: Membrane, Isoform 2: Membrane, Isoform 3: Secreted, Isoform 4: Secreted
Predicted Species
Rat (91%), Porcine (95%), Primate (100%), Monkey (99%), Bovine (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DDR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:10000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
101 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Rhesus Monkey (99%), Chimpanzee (100%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DDR1 Antibody

  • CAK
  • CD167 antigen-like family member A
  • CD167a antigen
  • CD167a
  • DDR
  • DDR1
  • discoidin domain receptor family, member 1
  • discoidin domain receptor tyrosine kinase 1
  • Discoidin receptor tyrosine kinase
  • EC 2.7.10
  • EC 2.7.10.1
  • EDDR1
  • ENTRK4
  • Epithelial discoidin domain receptor 1
  • HGK2
  • MCK10
  • MCK-10
  • NTRK4
  • Protein-tyrosine kinase 3A
  • PTK3A protein tyrosine kinase 3A
  • PTK3A
  • receptor, type 4
  • RTK6
  • TRK E
  • TrkE

Background

discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for DDR1 Antibody (NBP1-33134). (Showing 1 - 1 of 1 FAQ).

  1. I was wondering if you offer, or are planning on offering, any antibodies targeted to specific phosphorylation sites on the receptor tyrosine kinase DDR1.
    • At this time we do not offer and DDR1 antibodies specific for certain phosphorylation states.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for DDR1 Antibody (NBP1-33134)

Discover related pathways, diseases and genes to DDR1 Antibody (NBP1-33134). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on DDR1.

Further unraveling the role of gamma H2AX in DNA damage response
Our genome experiences a moderate amount of DNA damage in our cells on a daily basis.  This DNA damage can be in response to external environmental factors, or be a result of our internal metabolic processes going awry.  While normal rates of DNA ...  Read full blog post.

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Bioinformatics

Gene Symbol DDR1
Entrez