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Description

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]

Bioinformatics

Entrez	780 Human
Uniprot	NP_001945.3 Human
Product By Gene ID	780
Alternate Names	CAK CD167 antigen-like family member A CD167a antigen CD167a DDR DDR1 discoidin domain receptor family, member 1 discoidin domain receptor tyrosine kinase 1 Discoidin receptor tyrosine kinase EC 2.7.10 EC 2.7.10.1 EDDR1 ENTRK4 Epithelial discoidin domain receptor 1 HGK2 MCK10 MCK-10 NTRK4 Protein-tyrosine kinase 3A PTK3A protein tyrosine kinase 3A PTK3A receptor, type 4 RTK6 TRK E TrkE

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