Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.05% BSA
0.05% Sodium Azide
Protein G purified
Alternate Names for DAP Kinase 2 Antibody
DAP kinase 2
DAP-kinase-related protein 1 beta isoform
DAP-kinase-related protein 1
death-associated protein kinase 2
DAPK2 is a 42 KDa calcium/calmodulin-dependant serine/threonine kinase localized in the cytoplasm. A member of DAP kinase family, DAPK2 has an N-terminal protein kinase domain, a conserved CAM binding domain and a 40A.A C-terminal tail required for homodimerization. Inactive DAPK2 is phosphorylated at conserved 'Ser-308', an inhibitory autophosphorylation site located within the CAM binding domain and is critical in inhibiting DAPK2 catalytic activation. Pro-apoptotic function of DAPK2 is activated by dephosphorylation, increase of intracellular Ca2+ levels, Ca2+ induced Calmodulin binding and homodimerization. Reports suggest DAPK2 along with DAPK1 induces membrane blebbing and formation of autophagic vesicles and plays a vital role in TGF-induced caspase-dependent Type-I and IFNa- induced caspase-independent autophagic type II cell death signaling. Northern Blot analysis detected abundant expression of DAPK2 mRNA in heart, lung and skeletal muscle.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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