DAP Kinase 2 Antibody

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Western Blot: DAP Kinase 2 Antibody [NB100-56344] - Analysis of DAPK2 in rat kidney whole cell lysate using this antibody.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

DAP Kinase 2 Antibody Summary

Immunogen
This antibody was developed against KLH-conjugated synthetic peptides corresponding to amino acids 325-342 and 347-364 of human DAPK2. It will cross-react with mouse and rat DAPK2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DAPK2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2-4 ug/ml
Positive Control
Kidney Lysate (NB820-59709)
DAP Kinase 2 Lysate (NBL1-09717)
Publications
Read Publication using NB100-56344.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for DAP Kinase 2 Antibody

  • DAP kinase 2
  • DAP-kinase-related protein 1 beta isoform
  • DAP-kinase-related protein 1
  • death-associated protein kinase 2
  • DRP1
  • DRP-1MGC119312
  • EC 2.7.11
  • EC 2.7.11.1

Background

DAPK2 is a 42 KDa calcium/calmodulin-dependant serine/threonine kinase localized in the cytoplasm. A member of DAP kinase family, DAPK2 has an N-terminal protein kinase domain, a conserved CAM binding domain and a 40A.A C-terminal tail required for homodimerization. Inactive DAPK2 is phosphorylated at conserved 'Ser-308', an inhibitory autophosphorylation site located within the CAM binding domain and is critical in inhibiting DAPK2 catalytic activation. Pro-apoptotic function of DAPK2 is activated by dephosphorylation, increase of intracellular Ca2+ levels, Ca2+ induced Calmodulin binding and homodimerization. Reports suggest DAPK2 along with DAPK1 induces membrane blebbing and formation of autophagic vesicles and plays a vital role in TGF-induced caspase-dependent Type-I and IFNa- induced caspase-independent autophagic type II cell death signaling. Northern Blot analysis detected abundant expression of DAPK2 mRNA in heart, lung and skeletal muscle.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for DAP Kinase 2 Antibody (NB100-56344)(1)

We have publications tested in 1 application: WB.


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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol DAPK2
Entrez
Uniprot