DAP Kinase 2 Products

Antibodies
DAP Kinase 2 Antibody (1C5)
DAP Kinase 2 Antibody (1C5)
Species: Hu, Mu, Rt, Ca, Mk
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Mouse Monoclonal
DAP Kinase 2 Antibody
DAP Kinase 2 Antibody
NB100-56344
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
DAP Kinase 2 Antibody
DAP Kinase 2 Antibody
NB100-863
Species: Hu, Mu
Applications: WB, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
Lysates
DAP Kinase 2 Overexpression L ...
DAP Kinase 2 Overexpression Lysate...
NBL1-09717
Applications: WB
Proteins
DAP Kinase 2 Partial Recombin ...
DAP Kinase 2 Partial Recombinant P...
H00023604-Q01
Species: Hu
Applications: WB, ELISA, PA
DAP Kinase 2 Peptide
DAP Kinase 2 Peptide
NBP1-77291PEP
Species: Hu
Applications: AC
RNAi
DAP Kinase 2 RNAi
DAP Kinase 2 RNAi
H00023604-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Protein kinase termed death-associated protein kinase 2 (DAPK2) dependant on calcium/calmodulin (Ca2+/CaM) contains an N-terminal protein kinase domain followed by a conserved CaM-binding domain with significant homologies to those of DAP kinase, a protein kinase involved in apoptosis. Overexpression of DAPK2 significantly induced the morphological changes characteristic of apoptosis. Results indicate that DAPK2 is an additional member of DAP kinase family involved in apoptotic signaling (1). The region of homology spans the catalytic domain and the CaM-regulatory region, whereas the remaining C-terminal part of the protein differs completely from DAP kinase and displays no homology to any known protein. The catalytic domain is also homologous to the recently identified ZIP kinase and to a lesser extent to the catalytic domains of DRAK1 and -2 (2). DAPK2 has a novel regulatory mechanism that controls its pro-apoptotic functions. It comprises a single autophosphorylation event mapped to Ser308 within the CaM regulatory domain. A negative charge at this site reduces both the binding to CaM and the formation of DRP-1 homodimers (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 23604
Alternate Names
  • EC 2.7.11
  • EC 2.7.11.1
  • DAP-kinase-related protein 1
  • DAP kinase 2
  • DAP-kinase-related protein 1 beta isoform
  • DRP-1MGC119312
  • DRP1
  • death-associated protein kinase 2

Research Areas for DAP Kinase 2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cellular Markers

PTMs for DAP Kinase 2

Learn more about PTMs related to DAP Kinase 2.

Phosphorylation
Methylation

Bioinformatics Tool for DAP Kinase 2

Discover related pathways, diseases and genes to DAP Kinase 2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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