CXCR3 Antibody

Images

 
Western Blot: CXCR3 Antibody [NBP2-16044] - Various whole cell extracts (30ug) were separated by 10% SDS-PAGE, and the membrane was blotted with CXCR3 diluted at a dilution of 1:1000.
Immunohistochemistry-Paraffin: CXCR3 Antibody [NBP2-16044] - Paraffin-embedded human cervical carcinoma diluted at 1:500.
Immunohistochemistry-Paraffin: CXCR3 Antibody [NBP2-16044] - Paraffin-embedded human cervical carcinoma diluted at 1:500.

Product Details

Summary
Reactivity Hu, RMSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

CXCR3 Antibody Summary

Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human CXCR3. The exact sequence is proprietary.
Localization
Cell membrane
Predicted Species
Rhesus Macaque (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CXCR3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reviewed Applications
Read 1 Review rated 5
using
NBP2-16044 in the following applications:

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CXCR3 Antibody

  • CD183 antigen
  • CD183
  • chemokine (C-X-C motif) receptor 3
  • chemokine (C-X-C) receptor 3
  • CKR-L2IP-10 receptor
  • CMKAR3
  • C-X-C chemokine receptor type 3
  • CXCR3
  • CXC-R3
  • CXCR-3
  • G protein-coupled receptor 9CD182
  • GPR9
  • GPR9Mig-R
  • Interferon-inducible protein 10 receptor
  • IP10 receptor
  • IP10-R
  • Mig receptor
  • MigR

Background

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCR3 Antibody (NBP2-16044) (0)

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Review for CXCR3 Antibody (NBP2-16044) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Human.
We have 1 review tested in 1 application: IHC-P.

Reviews using NBP2-16044:
Filter by Applications
IHC-P
(1)
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Human
(1)
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Images Ratings Applications Species Date Details
 
reviewed by:
Anonymous
IHC-P Human 05/20/2016
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Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedTonsil
SpeciesHuman
Lot39735

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Recent Reviews

5
5
1
4
0
3
0
2
0
1
0

 
Anonymous
05/20/2016
Application: IHC-P
Species: Human

Bioinformatics

Gene Symbol CXCR3
Entrez
Uniprot