RIMS2 Antibody

Images

 
Western Blot: RIMS2 Antibody [NBP1-76905] - Analysis in human brain tissue lysate with antibody at 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: RIMS2 Antibody [NBP1-76905] - Immunofluorescence of Rim2 in Human Brain cells with Rim2 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: RIMS2 Antibody [NBP1-76905] - Human brain with Rims2 antibody at 5 ug/mL.
Western Blot: RIMS2 Antibody [NBP1-76905] - Rat brain tissue lysate with RIMS2 antibody at 1 ug/ml in the (A) absence or (B) presence of blocking peptide.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

RIMS2 Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide near the center of the human Rim2. The immunogen is located within amino acids 250 - 300 of Rim2.
Specificity
Multiple isoforms of RIM2 are known to exist. This antibody is predicted to have no cross-reactivity to other Rim proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RIMS2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Theoretical MW
128 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
RIMS2 Peptide (NBP1-76905PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for RIMS2 Antibody

  • DKFZp781A0653
  • KIAA0751RIM2OBOERAB3 interacting protein 3
  • non-small cell lung cancer RimL3a protein
  • non-small cell lung cancer RimL3c protein
  • nuclear protein
  • Rab-3-interacting molecule 2
  • rab3-interacting molecule 2
  • Rab-3-interacting protein 3
  • RAB3IP3
  • regulating synaptic membrane exocytosis 2
  • regulating synaptic membrane exocytosis protein 2
  • RIM 2

Background

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner. Rim2 is known to exist in multiple isoforms; this antibody should recognize most of them. This antibody is predicted to have no cross-reactivity to other Rim proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol RIMS2
Uniprot