CNTFR Antibody (MM0190-10L29) [Janelia Fluor® 646]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: MM0190-10L29
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 646

CNTFR Antibody (MM0190-10L29) [Janelia Fluor® 646] Summary

• Immunogen: Human recombinant CNTFR
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Mouse
• Gene: CNTFR
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for CNTFR Antibody (MM0190-10L29) [Janelia Fluor® 646]

• ciliary neurotrophic factor receptor alpha
• ciliary neurotrophic factor receptor subunit alpha
• ciliary neurotrophic factor receptor
• CNTF receptor subunit alpha
• CNTFR alpha
• CNTFR-alpha
• MGC1774

Background

CNTFR encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CNTFR