CNTFR Products

Description

CNTFR encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.

Bioinformatics

Entrez	1271 Human 12804 Mouse 313173 Rat
Uniprot	NP_001833 Human NP_671693 Human NP_671693.1 Human P26992 Human
Product By Gene ID	1271
Alternate Names	ciliary neurotrophic factor receptor alpha ciliary neurotrophic factor receptor subunit alpha ciliary neurotrophic factor receptor CNTF receptor subunit alpha CNTFR alpha CNTFR-alpha MGC1774

Diseases related to CNTFR

Discover more about diseases related to CNTFR.

Leukemia
Nervousness
Sclerosis
Alzheimer's Disease
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Carcinoma
Malignant Neoplasms
Neoplasms
Hypertrophy
Inflammation
Eating Disorders
Left Ventricular Hypertrophy
Neuroblastoma
Multiple Sclerosis
Obesity
Cholangiocarcinoma
Myasthenias

Pathways for CNTFR

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Secretion
Localization
Osteoblast Differentiation
Regeneration
Cell Death
Pathogenesis
Jak-stat Cascade
Programmed Cell Death
Osteoblast Development
Aging
Dna Methylation
Proteolysis
Eating Behavior
Endocytosis
Methylation
Neuroprotection
Cytokine Production
Reverse Transcription
System Development
Regulation Of Bone Resorption

Research Areas for CNTFR

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Growth and Development
Neuronal Cell Markers

PTMs for CNTFR

Learn more about PTMs related to CNTFR.

Phosphorylation
Methylation

Bioinformatics Tool for CNTFR

Discover related pathways, diseases and genes to CNTFR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.