CNTFR alpha Antibody [Biotin] Summary
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human CNTF R alpha
Detects human CNTF R alpha in Western blots. In Western blots (under non-reducing and reducing conditions), greater than 50% cross‑reactivity with recombinant rat CNTF sR alpha is observed.
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Packaging, Storage & Formulations
|Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CNTFR alpha Antibody [Biotin]
- Ciliary neurotrophic factor receptor subunit alpha;Cntfr
- CNTF R alpha
- CNTFR alpha
high-affinity CNTF receptor complex, which mediates the biological
action of CNTF, contains three proteins: the ligand-binding alpha subunit
(CNTF R alpha ), and the two signal-transducing proteins LIF R beta and gp130.
Whereas LIF R beta and gp130 are widely expressed in many cell types, the
expression of CNTF R alpha is restricted to the central and peripheral
nervous systems. cDNAs encoding
human and rat CNTF R alpha share 94% amino acid (aa) sequence
identity. Human CNTF R alpha cDNA encodes a 372 aa precursor protein with a 22 aa residue signal peptide and four potential
glycoslyation sites. CNTF R alpha differs from other cytokine receptors in
that it lacks transmembrane and cytoplasmic domains and is anchored to
cell membranes by a glycosylphosphatidylinositol (GPI) linkage. Similar
to other GPI-linked proteins, soluble CNTF receptor alpha (CNTF sR alpha ) can be
released from the cell surface by phosphatidylinositol-specific
phospholipase C. CNTF sR alpha can be released from skeletal muscle in
response to peripheral nerve injury and high concentrations of CNTF sR alpha
have also been detected in human cerebrospinal fluid. CNTF sR alpha binds
CNTF in solution and the complex can act on cells that express only LIF
R beta and gp130 but not CNTF R alpha .
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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