Orthogonal Strategies: Immunohistochemistry-Paraffin: Claudin-11 Antibody [NBP1-82470] - Analysis in human testis and pancreas tissues using NBP1-82470 antibody. Corresponding CLDN11 RNA-seq data are presented ...read more
Western Blot: Claudin-11 Antibody [NBP1-82470] - HUVEC (Human Umbilical Vein Endothelial Cells) lysate. Three dilutions were tested using the WES 12-230 kDa kit (left panel): Lanes 2-3, 1:100; Lanes 4-5, 1:50; and Lanes ...read more
Immunohistochemistry-Paraffin: Claudin-11 Antibody [NBP1-82470] - Staining of human Skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry-Paraffin: Claudin-11 Antibody [NBP1-82470] - Staining of human Cervix shows no positivity in squamous epithelial cells as expected.
Immunohistochemistry-Paraffin: Claudin-11 Antibody [NBP1-82470] - Staining of human Pancreas shows no positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: Claudin-11 Antibody [NBP1-82470] - Staining of human Testis shows strong membranous positivity in cells in seminiferous ducts.
Rat (89%). Human reactivity reported in scientific literature (PMID: 26339636). Mouse reactivity reported in scientific literature (PMID: 25630681).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2), 40% Glycerol
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for Claudin-11 Antibody
OSPOTMoligodendrocyte transmembrane protein
Oligodendrocyte specific protein belongs is a major component of central nervous system myelin that is necessary for normal CNS function. The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, and are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that the Claudin 11 protein determines the permeability between layers of myelin sheaths via focal adhesion and with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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