CD94 Antibody

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Western blot shows lysates of CLL‑1390 canine leukocytic round cell neoplasia cell line, HDLM human Hodgkin’s lymphoma cell line, and CTLL‑2 mouse cytotoxic T cell line. PVDF membrane was probed with 1 µg/mL of ...read more

Product Details

Summary
Reactivity Hu, Mu, CaSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

CD94 Antibody Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human CD94
Lys32-Ile179
Accession # Q13241
Specificity
Detects recombinant human CD94 in direct ELISAs and human, mouse, and canine CD94 in Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
KLRD1
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Sterile PBS to a final concentration of 0.2 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD94 Antibody

  • CD94 antigen
  • CD94
  • CD94natural killer cells antigen CD94
  • Killer cell lectin-like receptor subfamily D member 1
  • killer cell lectin-like receptor subfamily D, member 1
  • KLRD1
  • KP43
  • NK cell receptor

Background

CD94 (also NK cell receptor, KLRD1 and KP43) is a 27‑31 kDa glycoprotein member of the C-type lectin superfamily. It is expressed on NK cells, particularly those that are CD56bright, plus those that are CD56dim but secrete material amounts of IFN-gamma. CD94 forms covalent transmembrane (TM) heterodimers with NKG2A, B, C, E and H, and binds HLA-E (in human; Qa-1b in mouse) as part of a cellular homeostatic monitoring system. Amide-linkage based complexes with NKG2A are predicted to run at 70-80 kDa in SDS-PAGE. Depending upon the exact NKG2 partner, CD94 ligation can result in either NK cell activation (2C, 2H or 2E) or inhibition (2A or 2B). Human CD94 is a 179 amino acid (aa) type II TM protein. It possesses a short cytoplasmic segment (aa 1-10) plus a 158 aa extracellular region (aa 32-179) that contains one C-type lectin domain (aa 61-176). Multiple splice variants exist. One is a 149 aa, 19 kDa cytosolic protein that shows an Ala substitution for aa 3-34, while a second is a truncated, 104 aa, 17 kDa TM protein. A third isoform is 158 aa in length and 25 kDa in size, and shows a deletion of aa 34-54. Over aa 32-179, human CD94 shares 53% aa identity with mouse CD94.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KLRD1
Uniprot