CD68/SR-D1 Antibody [Biotin]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Biotin
• Concentration: LYOPH

CD68/SR-D1 Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CD68/SR-D1
  Asn22-Ile320
  Accession # AAB25811
• Specificity: Detects human CD68 in Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CD68
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD68/SR-D1 Antibody [Biotin]

• CD_antigen: CD68
• CD68 antigen
• CD68 molecule
• CD68
• DKFZp686M18236
• gp110
• LAMP4
• macrophage antigen CD68
• Macrosialin
• SCARD1
• scavenger receptor class D, member 1
• SRD1
• SR-D1

Background

CD68, also called Scavenger Receptor D1 (SR-D1) or macrosialin in mouse, is a 110 kDa type I transmembrane glycoprotein that belongs to the LAMP family of molecules (1). It contains a 300 amino acid (aa) extracellular region that is rich in threonine and serine, a likely attachment site for multiple carbohydrates. Human CD68 shares 74% aa sequence identity to mouse CD68 in the extracellular region. CD68 is found on monocytes and macrophages and serves as a scavenger receptor for oxidized LDL.

1. Holness, C.L. and D.L. Simmons (1993) Blood 81:1607.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CD68/SR-D1 Antibody (BAF2040)(1)

Publication using BAF2040

• Brownell J, Wagoner J, Lovelace E, Thirstrup D, Mohar I, Smith W, Giugliano S, Li K, Crispe I, Rosen H, Polyak S Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes. J Hepatol, 2013-06-12;59(4):701-8. 2013-06-12 [PMID: 23770038] (Cell Selection, Human)

Bioinformatics

• Gene Symbol: CD68
• Uniprot:
  • AAB25811()