CD42b/GPIb alpha Antibody (AK2) [Biotin]

• Reactivity: Hu
• Applications: ELISA, Flow, IP
• Clone: AK2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Biotin

CD42b/GPIb alpha Antibody (AK2) [Biotin] Summary

• Description: This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
• Additional Information: Clone AK2 was used by HLDA to establish CD designation.
• Immunogen: Made to Human CD42b
• Specificity: Recognises the human CD42b cell surface antigen, also known as platelet glycoprotein GP1B. CD42b is expressed by platelets and megakaryocytes. Clone AK2 has been reported to block the binding of von Willebrand Factor (VWF) to platelets (1).
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: GP1BA
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Immunoprecipitation
• Application Notes: Optimal dilution of this antibody should be experimentally determined.
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:29437579).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for CD42b/GPIb alpha Antibody (AK2) [Biotin]

• Antigen CD42b-alpha
• BP1BA
• BSS
• CD42b antigen
• CD42b
• CD42b-alpha
• glycoprotein Ib (platelet), alpha polypeptide
• Glycoprotein Ibalpha
• GP1B
• GP1BA
• GPIb alpha
• GP-Ib alpha
• GPIbA
• GPIb-alpha
• MGC34595
• platelet glycoprotein Ib alpha chain
• platelet membrane glycoprotein 1b-alpha subunit

Background

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GP1BA