CCR10/GPR2 Antibody

Immunohistochemistry: CCR10/GPR2 Antibody [NB100-707] - Paraffin section of human tonsil.

• Reactivity: Hu
• Applications: WB, ELISA, Flow, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated

CCR10/GPR2 Antibody Summary

• Immunogen: Synthetic peptide: VSWGHYSGDEEDAYSAEPLPELC, corresponding to amino acids 9-31 of Human CCR10.
• Localization: Cell Membrane
• Specificity: Peptide sequence is < 50 % identical to other human chemokine receptors in this region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CCR10
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry 1:12
  • Immunohistochemistry 1:125
  • Immunohistochemistry-Paraffin 1:125
  • Western Blot 1:500
• Control:

  CCR10/GPR2 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4, 140mM NaCl, 1mg/ml BSA
• Preservative: 0.1% Sodium Azide
• Purity: Affinity purified

Alternate Names for CCR10/GPR2 Antibody

• CC chemokine receptor 10
• C-C chemokine receptor type 10
• C-C CKR-10
• CC-CKR-10
• CCR10
• CCR-10
• chemokine (C-C motif) receptor 10
• G protein-coupled receptor 2
• GPR2
• GPR2G-protein coupled receptor 2

Background

Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR10 in particular is the receptor for the skin-associated CC chemokine CCL27 (CTACK) as well as the novel chemokine CCL28 which displays chemotactic activity for resting CD4+ and CD8+ T cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CCR10/GPR2 Antibody (NB100-707)(2)

Publications using NB100-707

• Hu SC, Chen GS, Wu CS et al. Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center. J Am Acad Dermatol 2009-03-01 [PMID: 19056145] (IHC-P, Human)
• Wick N, Haluza D, Gurnhofer E et al. Lymphatic Precollectors Contain a Novel, Specialized Subpopulation of Podoplaninlow, CCL27-Expressing Lymphatic Endothelial Cells. Am J Pathol;173(4):1202-1209. 2008-01-01 [PMID: 18772332]

Bioinformatics

• Gene Symbol: CCR10
• Entrez:
  • 2826(Human)