CCR10/GPR2 Products

Description

GPR2/CCR10, a Chemokine Receptor, encodes a protein that most closely resembles the interleukin-8 receptor. The keratinocyte-produced chemokine CCL27 activates CCR10 and is involved in T cell-mediated skin inflammation. GRP2/CCR10 has been reported to be ubiquitously expressed. Transcripts for this receptor have been identified in peripheral tissues including adult small intestine and fetal liver, testis, placenta, and skin. In the skin, this receptor is constitutively expressed in melanocytes, fibroblasts, and microvascular endothelial cells. It is also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in keratinocytes (Homey et al., 2000), dendritic cells, or in various brain regions (Marchese et al., 1994). ESTs have been isolated from brain, eye, and kidney libraries.

Bioinformatics

Entrez	2826 Human
Uniprot	P46092
Product By Gene ID	2826
Alternate Names	CC chemokine receptor 10 C-C chemokine receptor type 10 C-C CKR-10 CC-CKR-10 CCR10 CCR-10 chemokine (C-C motif) receptor 10 G protein-coupled receptor 2 GPR2 GPR2G-protein coupled receptor 2

Research Areas for CCR10/GPR2

Find related products by research area and learn more about each of the different research areas below.

GPCR
Immunology
Innate Immunity
Signal Transduction