CC Chemokine Receptor D6 Antibody - BSA Free

Immunohistochemistry: CC Chemokine Receptor D6 Antibody [NB100-704] - Immunohistochemistry on paraffin section of human spleen

Product Discontinued

CC Chemokine Receptor D6 Antibody - BSA Free Summary

• Immunogen: Synthetic peptide C-LATEDADSENSSFYYYDYLDEVAFML corresponding to the N-terminal extracellular domain of human D6.
• Specificity: Peptide sequence is < 50 % identical to other human chemokine receptors in this region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ACKR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:50000
  • Flow Cytometry 2-6 ul/10^6 cells in 100 ul
  • Immunocytochemistry/ Immunofluorescence 1:400
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:125
  • Western Blot 1:500
• Control:

  CC Chemokine Receptor D6 Overexpression Lysate
  Human Spleen Whole Tissue Lysate (Adult Whole Normal)

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 10mM KHPO4 and 0.14M NaCl
• Preservative: Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CC Chemokine Receptor D6 Antibody - BSA Free

• ACKR2
• C-C chemokine receptor D6
• CCBP2
• CCR10CCR9D6CC-chemokine-binding receptor JAB61
• chemokine (C-C) receptor 9
• chemokine binding protein 2
• Chemokine receptor CCR-10
• Chemokine receptor CCR-9
• chemokine receptor D6
• chemokine-binding protein 2
• Chemokine-binding protein D6
• CMKBR9
• CMKBR9chemokine (C-C motif) receptor 9
• D6
• hD6
• MGC126678
• MGC138250

Background

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. (provided by RefSeq, Jul 2008)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ACKR2
• Entrez:
  • 1238(Human)
• Uniprot:
  • O00590()