Canine IL-10 Quantikine ELISA Kit

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Product Details

Summary
Reactivity CaSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Canine IL-10 Quantikine ELISA Kit Summary

Background
The Quantikine Canine IL-10 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure canine IL-10 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant canine IL-10 and antibodies raised against the recombinant protein. Results obtained for naturally occurring canine IL-10 showed linear curves that were parallel to the standard curves obtain...ed using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural canine IL-10.
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Specificity
Natural and recombinant canine IL-10
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
IL10

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using CA1000.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Canine IL-10 Quantikine ELISA Kit

  • CSIF
  • CSIFMGC126450
  • Cytokine synthesis inhibitory factor
  • GVHDS
  • IL10
  • IL-10
  • IL10A
  • IL-10MGC126451
  • interleukin 10
  • interleukin-10
  • TGIF

Background

Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Treg and myeloid-derived suppressor cells (MDSC). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation and promoting muscle regeneration after injury, but it also contributes to the persistence of viral infections. IL-10 signals through a receptor complex composed of IL-10 R alpha and IL-10 R beta. IL-10 R beta additionally associates with IL-20 R alpha, IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-10 (CA1000)(13)

We have publications tested in 1 confirmed species: Canine.


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Canine
(13)
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Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using CA1000 Applications Species
S Kim, YS Hyun, HT Park, MK Shin, HS Yoo Mycobacterium intracellulare induces a Th17 immune response via M1-like macrophage polarization in canine peripheral blood mononuclear cells Scientific Reports, 2022;12(1):11818. 2022 [PMID: 35821058] (Canine) Canine
E Gugliandol, P Licata, AF Peritore, R Siracusa, R D'Amico, M Cordaro, R Fusco, D Impellizze, R Di Paola, S Cuzzocrea, R Crupi, CD Interlandi Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood Veterinary sciences, 2021;8(9):. 2021 [PMID: 34564578] (Canine) Canine
H Suzuki, N Oshima, T Watari Effect of modified ultrafiltration on cytokines and hemoconcentration in dogs undergoing cardiopulmonary bypass J Vet Med Sci, 2020;0(0):. 2020 [PMID: 33012753] (Canine) Canine
A Kathrani, E Hall A preliminary study assessing cytokine production following ex vivo stimulation of whole blood with diet in dogs with chronic enteropathy BMC Vet. Res., 2019;15(1):185. 2019 [PMID: 31164117] (Canine) Canine
SH Lee, JC Ra, HJ Oh, MJ Kim, EMN Setyawan, YB Choi, JW Yang, SK Kang, SH Han, GA Kim, BC Lee Clinical Assessment of Intravenous Endothelial Progenitor Cell Transplantation in Dogs Cell Transplant, 2019;0(0):9636897188216. 2019 [PMID: 31018670] (Canine) Canine
J Junginger, K Raue, K Wolf, E Janecek, VM Stein, A Tipold, AR Günzel-Ape, C Strube, M Hewicker-T Zoonotic intestinal helminths interact with the canine immune system by modulating T cell responses and preventing dendritic cell maturation Sci Rep, 2017;7(1):10310. 2017 [PMID: 28871165] (Canine) Canine
L Leclerc, C Thorin, J Flanagan, V Biourge, S Serisier, P Nguyen Higher neonatal growth rate and body condition score at 7�months are predictive factors of obesity in adult female Beagle dogs BMC Vet. Res., 2017;13(1):104. 2017 [PMID: 28407742] (Canine) Canine
C R Bjørnvad Immunometabolic parameters in overweight dogs during weight loss with or without an exercise program Domest. Anim. Endocrinol., 2016;59(0):58-66. 2016 [PMID: 27951413] (Canine) Canine
Ferreira J, Silva L, Longo-Maugeri I, Katz S, Barbieri C Use of a recombinant cysteine proteinase from Leishmania (Leishmania) infantum chagasi for the Immunotherapy of canine visceral Leishmaniasis. PLoS Negl Trop Dis, 2014;8(3):e2729. 2014 [PMID: 24625516] (Canine) Canine
Esch K, Juelsgaard R, Martinez P, Jones D, Petersen C Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function. J Immunol, 2013;191(11):5542-50. 2013 [PMID: 24154626] (Canine) Canine
Show All 13 Publications.

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Blogs on IL-10.


  Read full blog post.

Success of combined IL-10 and IL-12 therapy in colon cancer depends on IFN-gamma and gut barrier integrity
By Jamshed Arslan, Pharm. D., PhD. Colon cancer is responsible for over 600,000 deaths per year worldwide. Colon cancer can be classified into two categories: mismatch repair (MMR)-deficient and MMR-proficient cancers...  Read full blog post.

How To Identify B Cell Subsets Using Flow Cytometry
By Victoria OsinskiUsing Flow Cytometry to Identify B Cell SubsetsIdentifying cellular subsets by flow cytometry requires careful and thorough planning in order to ensure the correct subset of cells are identified a...  Read full blog post.

PPAR gamma - An important target in human metabolism
Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells by interacting with members of the nuclear hormone receptor superfamily known as peroxisome proliferator activated receptors (PPARs). There are f...  Read full blog post.

CD11b: Marker for a New Type of B Cell that Participates in Cell-Mediated Immunity
Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus a...  Read full blog post.

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Bioinformatics

Gene Symbol IL10