C1qR1/CD93 Antibody [Unconjugated]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Unconjugated
• Concentration: LYOPH

C1qR1/CD93 Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse C1q R1/CD93
  Ala23-Asn572
  Accession # O89103
• Specificity: Detects mouse C1q R1/CD93 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: CD93
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for C1qR1/CD93 Antibody [Unconjugated]

• AA4 Antigen
• C1q R1
• C1q receptor 1
• C1q Rp
• C1q/MBL/SPA receptor
• C1qR(P)
• C1qR1
• C1qRp
• CD93 antigenC1qR
• CD93 molecule
• CD93
• CDw93C1QR1
• Collectin Receptor
• Complement component 1 q subcomponent receptor 1
• complement component 1, q subcomponent, receptor 1
• complement component C1q receptor
• dJ737E23.1
• ECSM3
• Ly68
• Matrix-remodeling-associated protein 4
• matrix-remodelling associated 4
• MXRA4

Background

C1q R1, also known as C1q Rp, CD93, Cell Surface Antigen AA4 and lymphocyte antigen 68, is a type I transmembrane protein. It contains a C-type lectin family domain and five EGF-like domains in its extracellular region, as well as a tyrosine kinase-recognition motif in its cytoplasmic region. It is most abundantly expressed on endothelial cells and platelets and is also expressed in neutrophils, glial cells and monocytes. C1q R1 is a marker for early multipotent hematopoietic cells and may participate in C1q/MBL/SPA-mediated enhancement of phagocytic function by monocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for C1qR1/CD93 Antibody (AF1696)(10)

Publications using AF1696

• Raudales, A;Schager, B;Hancock, D;Narayana, K;Sharma, S;Reeson, P;Oshanyk, A;Cheema, M;Körbelin, J;Brown, CE; Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner Cell reports 2024-11-28 [PMID: 39612246] (Immunohistochemistry, Mouse, Transgenic Mouse)
• Yao, K;Yang, M;Shu, M;Wang, T;Gao, D;Zhou, L;Wang, G;Zhang, Z;Tang, J; SOX4 promotes vascular abnormality in glioblastoma and is a novel target to improve drug delivery Translational oncology 2024-09-16 [PMID: 39288695] (Immunohistochemistry, Mouse)
• Hao, X;Shen, Y;Liu, J;Alexander, A;Wu, L;Xu, Z;Yu, L;Gao, Y;Liu, F;Chan, HL;Li, CH;Ding, Y;Zhang, W;Edwards, DG;Chen, N;Nasrazadani, A;Ueno, NT;Lim, B;Zhang, XH; Solid tumour-induced systemic immunosuppression involves dichotomous myeloid-B cell interactions Nature cell biology 2024-09-12 [PMID: 39266726] (Immunohistochemistry, Immunocytochemistry, Human)
• Beter, M;Abdollahzadeh, A;Pulkkinen, HH;Huang, H;Orsenigo, F;Magnusson, PU;Yl�-Herttuala, S;Tohka, J;Laakkonen, JP; SproutAngio: an open-source bioimage informatics tool for quantitative analysis of sprouting angiogenesis and lumen space Scientific reports 2023-05-04 [PMID: 37142637] (IHC, Mouse)
• Fabrizio Orsenigo, Lei Liu Conze, Suvi Jauhiainen, Monica Corada, Francesca Lazzaroni, Matteo Malinverno et al. Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution eLife 11/3/2020 [PMID: 33138917]
• M Lee, HS Park, MY Choi, HZ Kim, SJ Moon, JY Ha, A Choi, YW Park, JS Park, EC Shin, CW Ahn, S Kang Significance of Soluble CD93 in Type 2 Diabetes as a Biomarker for Diabetic Nephropathy: Integrated Results from Human and Rodent Studies J Clin Med, 2020-05-08;9(5):. 5/8/2020 [PMID: 32397261]
• R Lugano, K Vemuri, D Yu, M Bergqvist, A Smits, M Essand, S Johansson, E Dejana, A Dimberg CD93 promotes ?1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis J. Clin. Invest., 2018-06-25;128(8):3280-3297. 2018-06-25 [PMID: 29763414] (IHC, Human, Mouse)
• Greenlee-Wacker MC, Briseno C, Galvan M, Moriel G, Velazquez P, Bohlson SS Membrane-associated CD93 regulates leukocyte migration and C1q-hemolytic activity during murine peritonitis. J. Immunol., 2011-08-17;187(6):3353-61. 2011-08-17 [PMID: 21849679] (ELISA Development, Mouse)
• Ghazal Zekavat, Raha Mozaffari, Vanessa J. Arias, Susan Y. Rostami, Armen Badkerhanian, Andrea J. Tenner et al. A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state Immunogenetics 6/1/2010 [PMID: 20387063]
• Ayers M, Fargnoli J, Lewin A, Wu Q, Platero JS Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist. Cancer Res., 2007-07-15;67(14):6899-906. 2007-07-15 [PMID: 17638901] (IHC-P, Human)

Bioinformatics

• Gene Symbol: CD93
• Uniprot:
  • O89103()