Biological Strategies: Western Blot: BRCA1 [p Ser1423] Antibody [NB100-226] - Detection of Human Phospho BRCA1 (S1423) by Western Blot. Samples : Whole cell lysate (50 ug) from HeLa cells treated with 100 uM ...read more
Biological Strategies: Western Blot: BRCA1 [p Ser1423] Antibody [NB100-226] - Detection of Brca1 phospho Ser 1423 by Western blot using NB 100-226. Sample whole cell lysate (25 mcg/lane) from HeLa cells treated ...read more
Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1423 according to the numbering given in entry NP_009225.1.
Monkey (100%), Primate (100%). Backed by our 100% Guarantee.
Immunogen affinity purified
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Use in FLOW cytometry reported in scientific literature ( PMID 24965603)
220 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
breast and ovarian cancer susceptibility protein 1
breast and ovarian cancer sususceptibility protein
breast cancer 1, early onset
breast cancer type 1 susceptibility protein
BRCA 1 contains at least two nuclear localization signals and is proposed to be a tumor suppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cell cycle progression. The amount of BRCA protein is highest during S phase and remains elevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1 function confers an increased susceptibility for both breast and ovarian cancer.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
The recent relationship of BRCA1 and 53BP1 The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage. DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m... Read full blog post.
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53BP1 - DNA damage is no fun The 53BP1 (p53 binding protein 1) was initially believed to be a p53 transcriptional enhancing partner, but it has now been established as an ataxia telangiectasia mutated (ATM) substrate. As a late DNA damage response (DDR) marker, 53BP1 appears duri... Read full blog post.
Breast Cancer Infographic Breast cancer is caused by malignant cells developing in breast tissue. It is the most commonly diagnosed cancer in women, but advancements in treatment options have seen the death rate decline since the 1990s. Common warning signs of breast cancer in... Read full blog post.
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BRCA1: Breast Cancer and Beyond BRCA1, also known as breast cancer type 1 susceptibility protein and RING finger protein 53, belongs to a class of genes known as tumor suppressors. BRCA1 regulates cell growth and division, and is also involved in DNA repair. There have been hundreds... Read full blog post.
Fanconi Antibodies and Cancer Research We at Novus Biologicals have an extensive antibody databasedevoted to the 13 Fanconi anaemia complementation (FANC) genes, which are involved in the recognition and repair of damaged DNA.The core complex of 8 proteins (FANCA, B, C, E, F, G, L and M)... Read full blog post.
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