Rad51 Antibody Reveals a Canine Model for Human Breast Cancer

Fri, 02/11/2011 - 07:56

Our antibody catalog includes an extensive range of Rad51 antibody reagents. Encoded by the RAD51 gene, the Rad51 protein plays a vital role in DNA repair, interacting with several other proteins, including BRCA1 and BRCA2, to effect homologous recombination at double-strand breaks. In 2010, German Rad51 antibody studies showed Rad51 levels were significantly raised in canine metastatic tumors. In general there was significant correlation between canine and human oncogenes, suggesting a possible animal model for human breast cancer.

Double-strand breaks (DSBs) are extremely common, and are caused by a number of environmental factors including ionizing radiation, UV light and certain chemicals. They also occur naturally when genetic material is exchanged during cell division. Genetic changes of BRCA and RAD51 are known to dramatically increase the risk of breast cancer in humans. BRCA and RAD51 mutations are often found together; RAD51/BRCA binding could play a tumor-suppressive role in normal cells.

Western Blot: Rad51 Antibody

Rad51 performs an important role at DNA breakage sites, encasing the break in a protein sheath – the first stage in DSB repair. Rad51 antibody studies have shown BRCA2 regulates the process by transporting Rad51 to breakage sites. The action of BRCA1 is less clear, but it is thought to play a role in activating Rad51 following DNA damage. Rad51 antibody research is integral to developing novel therapies for human breast cancer.

Recently, R. Klopfleisch, et al., of the Freie University, Berlin, identified 1,011 genes which were significantly modified in canine mammary tumors - including 265 of relevance to humans, including RAD51. This suggests a useful animal model for human research.

Novus Biologicals offers many RAD51 reagents for your research needs including:

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