beta-3 Adrenergic R/ADRB3 Antibody

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Immunocytochemistry/ Immunofluorescence: beta-3 Adrenergic R/ADRB3 Antibody [NBP2-68782] - Immunohistochemical staining of human caudate shows strong positivity in neuronal projections.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

beta-3 Adrenergic R/ADRB3 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: TCAPPEGVPACGRRPARLLPLREHR
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ADRB3
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
Application Notes
Recommended conditions for IHC,Retrieval method: HIER pH6
Control Peptide
beta-3 Adrenergic R/ADRB3 Recombinant Protein Antigen (NBP2-68782PEP)

Reactivity Notes

Mouse 84%

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for beta-3 Adrenergic R/ADRB3 Antibody

  • ADRB3
  • ADRB3R
  • adrenergic, beta-3-, receptor
  • B3AR
  • beta-3 Adrenergic R
  • beta-3 adrenergic receptor
  • beta3 AdrenergicR
  • beta-3 AdrenergicR
  • Beta-3 adrenoceptor
  • Beta-3 adrenoreceptor
  • BETA3AR
  • FLJ99960

Background

The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure; ADRB3 is also one of the molecular targets under active research in the treatment of obeisity. Beta-3 adrenoceptor expression has been documented in adipose, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of ADRB3. ESTs have been isolated from heart/melanocyte/uterus and placenta libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ADRB3