beta-3 Adrenergic R/ADRB3 Products

Antibodies
beta-3 Adrenergic R/ADRB3 Ant ...
beta-3 Adrenergic R/ADRB3 Antibody...
MAB9419
Species: Hu
Applications: Flow, ICC
Host: Mouse Monoclonal
beta-3 Adrenergic R/ADRB3 Ant ...
beta-3 Adrenergic R/ADRB3 Antibody
NLS4198
Species: Hu, GP
Applications: IHC-P
Host: Rabbit Polyclonal
beta-3 Adrenergic R/ADRB3 Ant ...
beta-3 Adrenergic R/ADRB3 Antibody
NBP2-29495
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
beta-3 Adrenergic R/ADRB3 Ove ...
beta-3 Adrenergic R/ADRB3 Overexpr...
H00000155-T01
Species: Hu
Applications: WB
beta-3 Adrenergic R/ADRB3 Ove ...
beta-3 Adrenergic R/ADRB3 Overexpr...
NBP2-11174
Applications: WB
Proteins
Recombinant Human beta-3 Adre ...
Recombinant Human beta-3 Adrenergi...
H00000155-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human beta-3 Adre ...
Recombinant Human beta-3 Adrenergi...
H00000155-G01
Species: Hu
RNAi
beta-3 Adrenergic R/ADRB3 RNA ...
beta-3 Adrenergic R/ADRB3 RNAi
H00000155-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure; ADRB3 is also one of the molecular targets under active research in the treatment of obeisity. Beta-3 adrenoceptor expression has been documented in adipose, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of ADRB3. ESTs have been isolated from heart/melanocyte/uterus and placenta libraries.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 155
Alternate Names
  • B3AR
  • BETA3AR
  • ADRB3R
  • Beta-3 adrenoreceptor
  • beta-3 adrenergic receptor
  • Beta-3 adrenoceptor
  • FLJ99960
  • adrenergic, beta-3-, receptor

Research Areas for beta-3 Adrenergic R/ADRB3

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GPCR
Neuroscience

PTMs for beta-3 Adrenergic R/ADRB3

Learn more about PTMs related to beta-3 Adrenergic R/ADRB3.

Cleavage

Bioinformatics Tool for beta-3 Adrenergic R/ADRB3

Discover related pathways, diseases and genes to beta-3 Adrenergic R/ADRB3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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