Immunohistochemistry-Paraffin: beta-1 Adrenergic R/ADRB1 Antibody [NB600-978] - Negative Control showing staining of paraffin embedded Human Heart, with no primary antibody.
Immunohistochemistry-Paraffin: beta-1 Adrenergic R/ADRB1 Antibody [NB600-978] - Staining of paraffin embedded Human Heart. Antibody at 4 ug/mL. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
Assay Standarization (beating frequency) successful usage of rat cardiomyocytes is reported in scientific literature (PMID: 20117461). IP successful usage on DNA aptamers in vitro is reported in scientific literature (PMID: 21868696, 22850243). Use In vitro assay reported in scientific literature (PMID: 29538413). Use in Western blot reported in scientific literature (PMID: 31265816).
Theoretical MW
51 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Mouse reactivity reported in scientific literature (PMID: 16210849). Rat reactivity reported in scientific literature (PMID: 20117461).
Packaging, Storage & Formulations
Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified
Alternate Names for beta-1 Adrenergic R/ADRB1 Antibody
ADRB1
ADRB1R
ADRB1RRHR
adrenergic, beta-1-, receptor
B1AR
beta-1 Adrenergic R
beta-1 adrenergic receptor
beta1 AdrenergicR
beta-1 AdrenergicR
Beta-1 adrenoceptor
Beta-1 adrenoreceptor
BETA1AR
Background
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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