BCMA/TNFRSF17 Antibody [Unconjugated] Summary
Mouse myeloma cell line NS0-derived recombinant human BCMA/TNFRSF17
Accession # Q6PE46
Detects human BCMA in ELISAs and Western blots. In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant human (rh) APRIL, rhBAFF, rhTACI, and recombinant mouse BCMA is observed.
<0.10 EU per 1 μg of the antibody by the LAL method.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Western Blot 0.1 ug/mL
- Flow Cytometry 0.25 ug/10^6 cells
- Blockade of Receptor-ligand Interaction
- ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL
- ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
- ELISA Standard (Matched Pair)
ELISA Capture: Human BCMA/TNFRSF17 Antibody (Catalog # AF193)
ELISA Detection: Human BCMA/TNFRSF17 Biotinylated Antibody (Catalog # BAF193)
Standard: Recombinant Human BCMA/TNFRSF17 Fc Chimera (Catalog # 193-BC)
Read 1 Review rated 5 using
AF193 in the following applications:
Packaging, Storage & Formulations
|Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for BCMA/TNFRSF17 Antibody [Unconjugated]
- B cell maturation antigen
- B-cell maturation protein
- BCMAtumor necrosis factor receptor superfamily member 17
- BCMB-cell maturation factor
- CD269 antigen
- tumor necrosis factor receptor superfamily, member 17
BCMA, B cell maturation, is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development, function and regulation. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity.
- Madry, C. et al. (1998) Int. Immunol. 10:1693.
- Gras, M. et al. (1995) Int. Immunol. 7:1093.
- Kwon, B. et al. (1999) Curr. Opin. Immunol. 11:340.
- Marsters, S. et al. (2000) Curr. Biol. 10:785.
- Thompson, J. et al. (2000) J. Exp. Med. 192:129.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Species: Hu, Mu
Applications: WB, IHC, IHC-P
Applications: WB, Flow, IHC, CyTOF-ready, Neut
Applications: WB, ELISA
Species: Hu, Mu, Bv, Xp
Applications: WB, IHC, IHC-Fr
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC-Fr, IHC-P
Species: Hu, Rb
Applications: WB, Flow, IHC-P, KO
Applications: Flow, Func, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
Species: Hu, Mu, Rt, Po
Applications: WB, IHC, IHC-P, PEP-ELISA
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for BCMA/TNFRSF17 Antibody (AF193) (0)
Additional BCMA/TNFRSF17 Products
Bioinformatics Tool for BCMA/TNFRSF17 Antibody (AF193)
Discover related pathways, diseases and genes to BCMA/TNFRSF17 Antibody (AF193). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
PTMs for BCMA/TNFRSF17 Antibody (AF193)
Learn more about PTMs related to BCMA/TNFRSF17 Antibody (AF193).
Blogs on BCMA/TNFRSF17