TACI/TNFRSF13B/CVID Antibody

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Western Blot: TACI/TNFRSF13B/CVID Antibody [NB100-56516] - Analysis of A) human spleen, B) mouse spleen, C) human stomach, D) and mouse stomach lysate using TACI antibody at 2 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

TACI/TNFRSF13B/CVID Antibody Summary

Immunogen
This rabbit polyclonal antibody was developed against a synthetic peptide corresponding to amino acids 116-132 of human TACI. Human and mouse TACI amino acid sequences are 65% conserved in the immunogen.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TNFRSF13B
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Use in Immunohistochemistry reported in multiple pieces of scientific literature. Use in Immunohistochemistry-paraffin reported in scientific literature (PMID: 22512719).
Control
TACI/TNFRSF13B/CVID Overexpression Lysate
Publications
Read Publications using
NB100-56516 in the following applications:

  • IHC
    2 publications
  • 2 publications

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for TACI/TNFRSF13B/CVID Antibody

  • CD267 antigen
  • CD267
  • CVID
  • CVID2
  • FLJ39942
  • MGC133214
  • TACI
  • TACIMGC39952
  • TNFRSF13B
  • TNFRSF14B
  • Transmembrane activator and CAML interactor
  • tumor necrosis factor receptor 13B
  • tumor necrosis factor receptor superfamily member 13B
  • tumor necrosis factor receptor superfamily, member 13B

Background

Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and BlyS (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells (5). Recently two orphan receptors TACI (6) and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-kB, and AP-1. TACI is a type III transmembrane protein, as defined by the lack of a cleaved signal sequence and its N-terminal extracellular exposure. The cDNA codes for 293 amino acids with predicted molecular weight of approx. 32 kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Supplier Logo

Publications for TACI/TNFRSF13B/CVID Antibody (NB100-56516)(7)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC, IHC-P.


Filter By Application
IHC
(2)
IHC-P
(2)
All Applications
Filter By Species
Human
(5)
All Species
Showing Publications 1 - 7 of 7.
Publications using NB100-56516 Applications Species
Ohmatsu H, Sugaya M, Miyagaki T et al. BAFF levels are increased in lesional skin and sera in patients with cutaneous T-cell lymphoma. Br J Dermatol. 2012 Aug [PMID: 22512719] (IHC-P, Human)

Details:
TACl (IMG-249). 1. IHC(paraffin): Human cutaneous T-cell lymphoma skin lesions, Fig 2.
IHC-P Human
Marcel V, Petit I, Murray-Zmijewski F et al. Diverse p63 and p73 isoforms regulate Delta133p53 expression through modulation of the internal TP53 promoter activity. Cell Death Differ. 2012 May [PMID: 22075982] (Human) Human
Zaher M, Tang R, Bombarda I et al. Hyperforin induces apoptosis of chronic lymphocytic leukemia cells through upregulation of the BH3-only protein Noxa. Int J Oncol. 2012 Jan [PMID: 21947285]
Zaher Murhaf, Mirshahi Massoud, Nuraliev Yusuf et al. The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract. Int J Oncol. 2011 Oct [PMID: 21750864]
Pelekanou Vassiliki, Notas George, Theodoropoulou Katerina et al. Detection of the TNFSF members BAFF, APRIL, TWEAK and their receptors in normal kidney and renal cell carcinomas. Anal Cell Pathol (Amst). 2011 [PMID: 21483105] (IHC, Human) IHC Human
Alexaki VI, Notas G, Pelekanou V et al. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol. 2009 Nov 1 [PMID: 19828625] (IHC-P, Human)

Details:
TACI (IMG-249) IHC (paraffin): Human epithelial, breast, and renal peritumoral fat, Fig fat 1 & 2.
IHC-P Human
Pelekanou Vassiliki, Kampa Marilena, Kafousi Maria et al. Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas. BMC Cancer. 2008 [PMID: 18366696] (IHC, Human) IHC Human

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TNFRSF13B
Entrez
Uniprot