VMAT2 Antibody

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Product Details

Summary
Reactivity Hu, Mu, Rt, RbSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

VMAT2 Antibody Summary

Immunogen
Reacts with an internal sequence of the human, mouse and rat VMAT2 protein.
Specificity
VMAT2
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLC18A2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:100-1:250
  • Immunohistochemistry-Frozen 1:100-1:250
Application Notes
This antibody is useful for Western Blot. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 20815037). Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 24161354). The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
55.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB110-68123 in the following applications:

Reactivity Notes

Reacts with human, mouse, and rat VMAT2 protein. Rabbit reactivity reported in scientific literature (PMID: 20665056)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for VMAT2 Antibody

  • MGC120477
  • MNAT
  • monoamine neurotransmitter transporter
  • Monoamine transporter
  • SLC18A2
  • solute carrier family 18 (vesicular monoamine), member 2
  • Solute carrier family 18 member 2
  • SVAT
  • SVMT
  • SVMTMGC120478
  • synaptic vesicular amine transporter
  • VAT2
  • VAT2MGC26538
  • vesicle monoamine transporter type 2
  • vesicle monoamine/H+ antiporter
  • Vesicular amine transporter 2
  • VMAT2

Background

VMAT2 is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. It is a requisite for vesicular amine storage prior to secretion via exocytosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for VMAT2 Antibody (NB110-68123)(8)

We have publications tested in 3 confirmed species: Mouse, Rat, Rabbit.

We have publications tested in 3 applications: ICC/IF, IHC-Fr, WB.


Filter By Application
ICC/IF
(1)
IHC-Fr
(2)
WB
(6)
All Applications
Filter By Species
Mouse
(3)
Rat
(3)
Rabbit
(1)
All Species
Showing Publications 1 - 8 of 8.
Publications using NB110-68123 Applications Species
Ma, K;Han, C;Zhang, G;Guo, X;Xia, Y;Wan, F;Yin, S;Kou, L;Liu, L;Huang, J;Xiong, N;Wang, T; Reduced VMAT2 expression exacerbates the hyposmia in the MPTP model of Parkinson's disease Biochem. Biophys. Res. Commun. May 28 2019 [PMID: 30954223] (WB, Mouse) WB Mouse
Gemechu JM, Sharma A, Yu D et al. Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats Sci Rep 2018 Jan 24 [PMID: 29367643] (WB, Rat) WB Rat
Lin CC, Tung CS, Lin PH et al. Traumatic stress causes distinctive effects on fear circuit catecholamines and the fear extinction profile in a rodent model of posttraumatic stress disorder. Eur Neuropsychopharmacol. Sep 1 2016 [PMID: 27492886] (WB, Rat) WB Rat
Choi W, Kim H, Xia Z. JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death. Toxicology. 2014 Dec 09 [PMID: 25496994] (WB) WB
Hong F, Liu L, Fan RF et al. New perspectives of vesicular monoamine transporter 2 chemical characteristics in mammals and its constant expression in type 1 diabetes rat models. Transl Res. 2013 Oct 6 [PMID: 24161354] (IHC-Fr, ICC/IF, Rat) IHC-Fr, ICC/IF Rat
Shin EJ, Duong CX, Nguyen XK, Li Z, Bing G, Bach JH, Park DH, Nakayama K, Ali SF, Kanthasamy AG, Cadet JL, Nabeshima T, Kim HC. Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase C delta. Behav Brain Res;232(1):98-113. 2012 Apr 9. [PMID: 22512859] (WB, Mouse) WB Mouse
Iritani S, Sekiguchi H, Habuchi C et al. Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal region of genetic animal model of schizophrenia. Synapse;64(12):948-53. 2010 Dec. [PMID: 20815037] (IHC-Fr, Mouse) IHC-Fr Mouse
Sala G, Brighina L, Saracchi E et al. Vesicular monoamine transporter 2 mRNA levels are reduced in platelets from patients with Parkinson's disease. J Neural Transm. 2010 Sep [PMID: 20665056] (WB, Rabbit) WB Rabbit

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol SLC18A2
Entrez
Uniprot