BACE-2 Antibody


Western Blot: BACE-2 Antibody [NBP1-77308] - Analysis of BACE2 in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with BACE2 antibody using this antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: BACE-2 Antibody [NBP1-77308] - Rat heart tissue with BACE2 antibody at 2 ug/ml.

Product Details

Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
1 mg/ml

Order Details

BACE-2 Antibody Summary

Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified


  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
BACE2 antibody can be used for detection of BACE2 by Western blot at 0.5 to 1 mg/ml.
Control Peptide
BACE-2 Peptide (NBP1-77308PEP)

Reactivity Notes


Alternate Names for BACE-2 Antibody

  • Asp 1
  • ASP1
  • ASP21
  • Aspartic-like protease 56 kDa
  • Aspartyl protease 1
  • BACE2
  • beta secretase 2
  • beta-secretase 2
  • beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
  • Beta-site amyloid precursor protein cleaving enzyme 2
  • Beta-site APP cleaving enzyme 2
  • beta-site APP-cleaving enzyme 2
  • beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease
  • CEAP1
  • Down region aspartic protease
  • Down syndrome region aspartic protease
  • EC 3.4.23
  • EC
  • memapsin-1
  • Membrane-associated aspartic protease 1
  • theta-secretase
  • transmembrane aspartic proteinase Asp1


Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for BACE-2 Antibody (NBP1-77308). (Showing 1 - 1 of 1 FAQ).

  1. Has this antibody been tested in tissue culture cells like HeLa or hek293 for Westerns?
    • We have not verified western blot in anything other than human heart lysate, which is shown in the image on our website. I checked on the Human Protein Atlas, and it looks like BACE2 should be present in most cell lines. Please see the following link for more information ENSG00000182240.

Secondary Antibodies


Isotype Controls

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Contact Information

Product PDFs


Gene Symbol BACE2

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