BACE-2 Products

Description

BACE2 (Memapsin 1) is a membrane-bound aspartic protease that is highly homologous with BACE1 (Memapsin 2). While BACE1 processes the amyloid precursor protein (APP) at a key step in generating the beta-amyloid peptide and presumably causes Alzheimer's disease (AD), BACE2 has not been demonstrated to be directly involved in APP processing, and its physiological functions remain to be determined. In vivo, BACE2 is expressed as a precursor protein containing pre-, pro-, protease, transmembrane, and cytosolic domains/peptides.

Bioinformatics

Entrez	25825 Human 288227 Rat 56175 Mouse
Uniprot	AAF17078 Human NP_036237 Human NP_620476 Human NP_620477 Human Q9NZL2 Human Q9Y5Z0 Human
Product By Gene ID	25825
Alternate Names	AEPLC Asp 1 ASP1 ASP21 Aspartic-like protease 56 kDa Aspartyl protease 1 beta secretase 2 beta-secretase 2 beta-site amyloid beta A4 precursor protein-cleaving enzyme 2 Beta-site amyloid precursor protein cleaving enzyme 2 Beta-site APP cleaving enzyme 2 beta-site APP-cleaving enzyme 2 beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease CEAP1 Down region aspartic protease Down syndrome region aspartic protease DRAPBAE2 EC 3.4.23 EC 3.4.23.45 Memapsin-1 memapsin-1 Membrane-associated aspartic protease 1 Theta-secretase theta-secretase transmembrane aspartic proteinase Asp1

Research Areas for BACE-2

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Neuroscience