AVEN Antibody - BSA Free

Images

 
Western Blot: AVEN Antibody [NBP1-76764] - Raji cell lysate with Aven antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.
Immunocytochemistry/ Immunofluorescence: AVEN Antibody [NBP1-76764] - Immunofluorescence of AVEN in Human Spleen cells with AVEN antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: AVEN Antibody [NBP1-76764] - Human spleen tissue with Aven antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml

Order Details

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Catalog# & Formulation Size Price

AVEN Antibody - BSA Free Summary

Immunogen
Antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human Aven. The immunogen is located within the first 50 amino acids of Aven. Amino Acid Squence: QAERGARGGRGRRP
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AVEN
Purity
Peptide affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1 ug/ml
Application Notes
Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.
Control Peptide
AVEN Peptide (NBP1-76764PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for AVEN Antibody - BSA Free

  • apoptosis, caspase activation inhibitor
  • cell death regulator Aven
  • PDCD12
  • programmed cell death 12

Background

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for AVEN Antibody (NBP1-76764) (0)

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Secondary Antibodies

 

Isotype Controls

Additional AVEN Products

Array NBP1-76764

Research Areas for AVEN Antibody (NBP1-76764)

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Bioinformatics

Gene Symbol AVEN
Uniprot