ATIC Antibody (F38 P7 H9) - BSA Free

Immunohistochemistry: ATIC Antibody (F38 P7 H9) [NBP2-66607] - Left and Center: Immunohistochemical staining of normal colon tissue and colon carcinoma tissue using ATIC antibody (Cat. No. NBP2-66607).Right: Western blot using ATIC antibody on HT29 cell lysate.

• Reactivity: Hu, Mu, Rt, Dr, Xp
• Applications: WB, IHC
• Clone: F38 P7 H9
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

ATIC Antibody (F38 P7 H9) - BSA Free Summary

• Description: Novus Biologicals Mouse ATIC Antibody (F38 P7 H9) - BSA Free (NBP2-66607) is a monoclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the human ATIC protein (Uniprot: P31939) and mouse myeloma Ag8563 cells.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ATIC
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1 ug/ml
  • Immunohistochemistry-Paraffin 1-5 ug/ml
  • Western Blot 5-10 ug/ml
• Application Notes: .

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.08% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for ATIC Antibody (F38 P7 H9) - BSA Free

• 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMPcyclohydrolase
• 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotidetransformylase/inosinicase
• AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme
• AICAR
• AICARFT
• AICARFT/IMPCHASE
• bifunctional purine biosynthesis protein PURH
• IMPCHASE
• phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
• PURHFLJ93545

Background

The bifunctional purine biosynthesis protein PURH contains phosphoribosylaminoimidazole carboxamide formyltransferase, also designated AICAR transformylase, IMP cyclohydrolase or Inosinicase. AICAR plays an important role in purine biosynthesis, specifically in the production of nucleotides and IMP. Defects in ATIC, the gene encoding for this protein, can cause AICArebosuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-ribotide, also designated ZMP, and its derivatives in erythrocytes and fibroblasts and also excrete very large amounts of AICA-riboside in the urine. Mental retardation, epilepsy, dysmorphic features and congenital blindness are all symptoms of this disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ATIC
• Uniprot:
  • P31939(Human)