Angiopoietin-like Protein 4/ANGPTL4 Antibody

Images

 
Western Blot: ANGPTL4 Antibody [NBP2-19016] - WB analysis of ANGPTL4 in 1) Human pancreas 2) Human lung 3) Human lymph node 4) Human adipose and 5) Human breast cancer lysate.
Immunocytochemistry/ Immunofluorescence: ANGPTL4 Antibody [NBP2-19016] - ANGPTL4 antibody was tested in U2OS cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Angiopoietin-like Protein 4/ANGPTL4 Antibody Summary

Immunogen
Synthetic peptide made to an internal sequence of human ANGPTL4 (within residues 150-250) [UniProt Q9BY76].
Localization
Secreted, vesicles
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ANGPTL4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:100
Application Notes
This ANGPTL4 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is observed ~48 kDa in multiple human tissues and 3T3-L1 cell lysates. In ICC/IF, vesicular staining was observed in U2OS cells.
Positive Control
Pancreas Lysate (NB820-59244)
Lymph Node Lysate (NB820-59242)

Reactivity Notes

Human and mouse

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Angiopoietin-like Protein 4/ANGPTL4 Antibody

  • Angiopoietin like Protein 4
  • angiopoietin-like 4
  • Angiopoietin-like Protein 4
  • ANGPTL4
  • ARP4fasting-induced adipose factor
  • FIAF
  • FIAFhepatic angiopoietin-related protein
  • Hepatic fibrinogen/angiopoietin-related protein
  • HFARP
  • HFARPANGPTL2
  • NL2
  • peroxisome proliferator-activated receptor (PPAR) gamma inducedangiopoietin-related protein
  • PGAR
  • PGARangiopoietin-related protein 4
  • pp1158
  • PPARG angiopoietin related protein

Background

Angiopoietin-related protein 4 (ANGPTL4), also known as angiopoietin-like protein 4, hepatic fibrinogen/angiopoietin-related protein, ARP4, HFARP, PGAR, NL2, FIAF, pp1158, and ANGPTL2, stops proliferation, movement, and tubule formation of endothelial cells and helps to prevent vascular leaking. ANGPTL4 is critical for regulation of glucose homeostasis and insulin sensitivity. The ANGPTL4 protein is a hormone that controls lipid metabolism and helps to regulate apoptosis. ANGPTL4 is characterized by hypoxia-induced expression in endothelial cells. During periods of hypoxia, ANGPTL4 is found in high levels in the sub-endothelial extracellular matrix, and the increased presence of ANGPTL4 hinders the adhesion of the endothelial cells. Many researchers believe ANGPTL4 can inhibit tumor motility and invasiveness as well as regulate angiogenesis. ANGPTL4 is a member of the angiopoietin/angiopoientin-like gene family and is found in high levels in the placenta, heart, liver, muscle, pancreas, and lungs. Lower levels of ANGPTL4 can be found in the brain and kidney. Researchers have found that increasing levels of ANGPTL4 in patients with breast cancer can prevent further cancer movement and growth as ANGPTL4 stops the tumor's ability to adhere (PMID: 21860410). Other researchers, however, believe higher levels of ANGPTL4 actually help colorectal cancer metastasize (PMID: 21937683). A third group of research indicates that screening for ANGPTL4 could help determine the origin of clear-cell carcinomas (PMID: 20454689).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ANGPTL4
Entrez
Uniprot