ALCAM/CD166 Antibody [Phycoerythrin]


Mouse Splenocytes either (A) activated or (B) resting were stained with Goat Anti-Mouse ALCAM/CD166 PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB1172P) and Rat Anti-Mouse B220/CD45R more

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Applications Flow

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ALCAM/CD166 Antibody [Phycoerythrin] Summary

Mouse myeloma cell line NS0-derived recombinant mouse ALCAM/CD166
Accession # AAC06342
Detects mouse ALCAM in direct ELISAs and Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant human (rh) ALCAM is observed, and less than 10% cross-reactivity with rhBCAM, recombinant mouse (rm) OCAM, and rmMAdCAM‑1 is observed.
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Flow Cytometry 10 uL/10^6 cells
Read Publications using
FAB1172P in the following applications:

Packaging, Storage & Formulations

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Supplied in a saline solution containing BSA and Sodium Azide.
Sodium Azide


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ALCAM/CD166 Antibody [Phycoerythrin]

  • activated leucocyte cell adhesion molecule
  • activated leukocyte cell adhesion moleculeFLJ38514
  • CD166 antigen
  • CD166
  • MEMDMGC71733


ALCAM, activated leukocyte cell adhesion molecule, is a type I membrane glycoprotein and a member of the immunoglobulin supergene family. It is also known as CD166, MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. ALCAM is expressed on thymic epithelial cells, activated B and T cells, and monocytes. ALCAM can bind itself homotypically and is also capable of binding CD6, NgCAM, and other, as of yet, unidentified brain proteins. ALCAM/CD6 interaction may be involved in T cell development and T cell regulation. Additionally, ALCAM/CD6 and ALCAM/NgCAM interactions may play roles in the nervous system. ALCAM has also been observed to be upregulated on highly metastasizing melanoma cell lines and may play a role in tumor migration. ALCAM is a 583 amino acid (aa) protein consisting of a 27 aa signal peptide, a 500 aa extracellular domain, a 24 aa transmembrane domain, and a 32 aa cytoplasmic domain. The extracellular domain of ALCAM contains 5 Ig-like domains of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation (1-4).  The ECD of mouse ALCAM shares 97.5% aa sequence identity with rat ALCAM ECD.

  1. Bowen, M.A. et al. (1995) J. Exp. Med. 181:2213.
  2. Aruffo, A. et al. (1997) Immunol. Today 18:498.
  3. Degen, W.G. et al. (1998) Am. J. Pathol. 152:805.
  4. Van Kempen, L. et al. (2001) J. Biol. Chem. 276:25783.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ALCAM/CD166 Antibody (FAB1172P)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.

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Showing Publications 1 - 6 of 6.
Publications using FAB1172P Applications Species
X He, SE Smith, S Chen, H Li, D Wu, PI Meneses-Gi, Y Wang, M Hembree, K Yi, X Zhao, F Guo, JR Unruh, LE Maddera, Z Yu, A Scott, A Perera, Y Wang, C Zhao, K Bae, A Box, JS Haug, F Tao, D Hu, DM Hansen, P Qian, S Saha, D Dixon, S Anant, D Zhang, EH Lin, W Sun, LM Wiedemann, L Li Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche Cell Reports, 2021-09-07;36(10):109674. 9/7/2021 [PMID: 34496236]
J Min, PN Vega, AC Engevik, JA Williams, Q Yang, LM Patterson, AJ Simmons, RJ Bliton, JW Betts, KS Lau, ST Magness, JR Goldenring, E Choi Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach Nat Commun, 2019-12-05;10(1):5549. 2019-12-05 [PMID: 31804471] (Flow Cytometry, Mouse) Flow Cytometry Mouse
KS Yan, O Gevaert, GXY Zheng, B Anchang, CS Probert, KA Larkin, PS Davies, ZF Cheng, JS Kaddis, A Han, K Roelf, RI Calderon, E Cynn, X Hu, K Mandleywal, J Wilhelmy, SM Grimes, DC Corney, SC Boutet, JM Terry, P Belgrader, SB Ziraldo, TS Mikkelsen, F Wang, RJ von Furste, NR Smith, P Chandrakes, R May, MAS Chrissy, R Jain, CA Cartwright, JC Niland, YK Hong, J Carrington, DT Breault, J Epstein, CW Houchen, JP Lynch, MG Martin, SK Plevritis, C Curtis, HP Ji, L Li, SJ Henning, MH Wong, CJ Kuo Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity Cell Stem Cell, 2017-07-06;21(1):78-90.e6. 2017-07-06 [PMID: 28686870] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Nicholas R. Smith, Paige S. Davies, Trevor G. Levin, Alexandra C. Gallagher, Douglas R. Keene, Sidharth K. Sengupta et al. Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell Homeostasis Cellular and Molecular Gastroenterology and Hepatology 5/1/2017 [PMID: 28462380]
Xingbin Hu, Mayra Garcia, Lihong Weng, Xiaoman Jung, Jodi L. Murakami, Bijender Kumar et al. Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche Nature Communications 10/10/2016 [PMID: 27721421]
Simonetti , Giorgia, Carette , Amanda, Silva , Kathryn, Wang , Haowei, De Silva , Nilushi, Heise , Nicole, Siebel , Christia, Shlomchik , Mark J, Klein , Ulf IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity. J Exp Med, 2013-12-09;210(13):2887-902. 2013-12-09 [PMID: 24323359] (Flow Cytometry, Mouse) Flow Cytometry Mouse

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Gene Symbol ALCAM