AdipoR2 Antibody

Immunohistochemistry-Paraffin: AdipoR2 Antibody [NBP1-28641] - human muscle

Immunohistochemistry-Paraffin: AdipoR2 Antibody [NBP1-28641] - human liver

• Reactivity: Hu, Mu, Rt, Pm
• Applications: WB, Simple Western, IHC, MA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated

AdipoR2 Antibody Summary

• Immunogen: Synthetic peptide (HFHGVSNLQEFRFMIGGGC) corresponding to aa 362-380 of the C-terminal domain of Human, Mouse and Rat ADPR 2 Receptor
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ADIPOR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:250
  • Protein Array
  • Simple Western 1:20
  • Western Blot 1:1000
• Application Notes: Use in PA reported in scientific literature (PMID:34279477).
  See Simple Western Antibody Database for Simple Western validation: Tested in Brain, separated by Size, antibody dilution of 1:20

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 1.0 mg/ml BSA
• Preservative: 0.1% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for AdipoR2 Antibody

• ACDCR2
• adiponectin receptor 2
• adiponectin receptor protein 2
• AdipoR2
• FLJ21432
• PAQR2
• PAQR2MGC4640
• Progestin and adipoQ receptor family member II

Background

Adiponectin Receptor 2 is the receptor for globular and full length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for AdipoR2 Antibody (NBP1-28641)(4)

Publications using NBP1-28641

• Yang S, Ma C, Wu H et al. Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway Pharmacol. Res. 2020-01-31 [PMID: 32014572] (WB, IHC-P, Mouse)
• Takeuchi S, Wada K, Uozumi Y et al. Adiponectin receptor 1 expression is associated with carotid plaque stability. Neurol India 2013-05-01 [PMID: 23860143] (IHC-P, Human)
• Daniele A, De Rosa A, Nigro E et al. Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease. The International Journal of Biochemistry & Cell Biology. 2012-01-03 [PMID: 22233975]

Bioinformatics

• Gene Symbol: ADIPOR2
• Entrez:
  • 79602(Human)
  • 68465(Mouse)
• Uniprot:
  • Q86V24(Mouse)