Adiponutrin/PNPLA3 Antibody (847516) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: IHC
• Clone: 847516
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Adiponutrin/PNPLA3 Antibody (847516) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human Adiponutrin/PNPLA3
  Arg160-Arg349
  Accession # Q9NST1
• Specificity: Detects human Adiponutrin/PNPLA3 in direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Adiponutrin/PNPLA3 Antibody (847516) [Alexa Fluor® 350]

• Acylglycerol O-acyltransferase
• Adiponutrin
• ADPN
• ADPNdJ796I17.1
• C22orf20
• Calcium-independent phospholipase A2-epsilon
• chromosome 22 open reading frame 20
• EC 2.3.1.-
• EC 2.7.7.56
• EC 3.1.1.3
• EC 4.2.3.4
• FLJ22012
• iPLA(2)epsilon
• iPLA2-epsilon
• patatin-like phospholipase domain containing 3
• patatin-like phospholipase domain-containing protein 3
• PNPLA3

Background

Human Adiponutrin (ADPN; also PNPLA3 and patatin-like phospholipase domain-containing protein 3) is a 53 kDa member of the PNPLA family of phospholipase A2 enzymes. It is expressed in white adipocytes. Adiponutrin is elevated in response to insulin and appears to act not as a phospholipase, but a molecule involved in anabolic pathways. ADPN is likely to be a type II transmembrane protein that is 481 amino acids (aa) in length. It contains one patatin domain (aa 10‑179) that is associated with in vitro enzyme activity and a transmembrane segment between aa 42‑62. There appear to be two splice variants. One shows a four aa deletion of aa 59‑62 and a second shows an alternate start site at Met379. Over aa 160‑349, human ADPN shares 61% aa identity with mouse Adiponutrin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.