Adiponutrin/PNPLA3 Products

Description

Human Adiponutrin (ADPN; also PNPLA3 and patatin-like phospholipase domain-containing protein 3) is a 53 kDa member of the PNPLA family of phospholipase A2 enzymes. It is expressed in white adipocytes. Adiponutrin is elevated in response to insulin and appears to act not as a phospholipase, but a molecule involved in anabolic pathways. ADPN is likely to be a type II transmembrane protein that is 481 amino acids (aa) in length. It contains one patatin domain (aa 10‑179) that is associated with in vitro enzyme activity and a transmembrane segment between aa 42‑62. There appear to be two splice variants. One shows a four aa deletion of aa 59‑62 and a second shows an alternate start site at Met379. Over aa 160‑349, human ADPN shares 61% aa identity with mouse Adiponutrin.

Bioinformatics

Uniprot	Q9NST1
Product By Gene ID	80339
Alternate Names	Acylglycerol O-acyltransferase Adiponutrin ADPN ADPNdJ796I17.1 C22orf20 Calcium-independent phospholipase A2-epsilon chromosome 22 open reading frame 20 EC 2.3.1.- EC 2.7.7.56 EC 3.1.1.3 EC 4.2.3.4 FLJ22012 iPLA(2)epsilon iPLA2-epsilon patatin-like phospholipase domain containing 3 patatin-like phospholipase domain-containing protein 3 PNPLA3