ACMSD Antibody - BSA Free

Immunohistochemistry-Paraffin: ACMSD Antibody [NBP1-86108] - Analysis in human kidney and cerebral cortex tissues. Corresponding ACMSD RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: ACMSD Antibody [NBP1-86108] - Staining of human liver shows weak to moderate cytoplasmic positivity in hepatocytes.

Immunohistochemistry-Paraffin: ACMSD Antibody [NBP1-86108] - Staining of human kidney shows moderate to strong cytoplasmic positivity in cells in tubules.

Immunohistochemistry-Paraffin: ACMSD Antibody [NBP1-86108] - Staining of human cerebral cortex shows no positivity in neurons as expected.

Immunohistochemistry-Paraffin: ACMSD Antibody [NBP1-86108] - Staining of human testis shows no positivity in cells in seminiferous ducts as expected.

Analysis in human liver tissue.

• Reactivity: Hu, Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

ACMSD Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: GVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNAL
• Predicted Species: Mouse (90%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ACMSD
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200-1:500
  • Western Blot 0.04 - 0.4 ug/ml
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  ACMSD Recombinant Protein Antigen (NBP1-86108PEP)

Reactivity Notes

Rat (87%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for ACMSD Antibody - BSA Free

• aminocarboxymuconate semialdehyde decarboxylase
• EC 4.1.1.45,2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
• Picolinate carboxylase

Background

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ACMSD
• Entrez:
  • 130013(Human)
• Uniprot:
  • Q8TDX5(Human)