Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
0.1% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.
This HIP1 Related antibody is useful for Western blot, where a band is observed at ~120 kDa representing HIP1 Related protein. One lower molecular weight band 80 kDa may also be observed. Immunoprecipitation and Immunohistochemistry were reported in scientific literature.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Closely related to the clathrin-mediated endocytosis regulator HIP1, HIP1R is important in cytoskeletal and membrane traffic. HIP1R prolongs the half-life of growth factor receptors, and helps maintain diversity of adult tissues. This functionality seems to only be relevant in mature systems; whereas, in early development from embryo to juvenile stages, HIP1R does not seem to be critical unless other related proteins are affected. In the absence of HIP1R, growth and differentiation seems to occur without any major effects; however, when both HIP1R and HIP1 are deleted, kypholordosis and dwarfism occurs. This seems to indicate that HIP1 and HIP1R share similar roles in vivo, and can mostly compensate for the absence of each other.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.