ABCA4 Antibody [DyLight 680]

Product Discontinued

ABCA4 Antibody [DyLight 680] Summary

• Immunogen: ABCA4. (Uniprot# P78363)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ABCA4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for ABCA4 Antibody [DyLight 680]

• ABC10
• ABCRRMP
• ARMD2DKFZp781N1972
• ATP binding cassette transporter
• ATP-binding cassette sub-family A member 4
• ATP-binding cassette transporter, retinal-specific
• ATP-binding cassette, sub-family A (ABC1), member 4
• ATP-binding transporter, retina-specific
• CORD3
• EC 3.6.3
• FFMFLJ17534
• photoreceptor rim protein
• retinal-specific ATP-binding cassette transporter
• retina-specific ABC transporter
• RIM ABC transporter
• RIM protein
• RmP
• RP19
• Stargardt disease protein
• STGD
• STGD1

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABCA4