ABCA4 Antibody

Product Discontinued

ABCA4 Antibody Summary

• Immunogen: Peptide with sequence C-KQQTESHDLPLHPR corresponding to C-Terminus according to NP_000341.2.
• Epitope: C-KQQTESHDLPLHPR
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ABCA4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
• Application Notes: WB: Preliminary experiments in human liver lysates and in mouse eye and rat retina lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for ABCA4 Antibody

• ABC10
• ABCRRMP
• ARMD2DKFZp781N1972
• ATP binding cassette transporter
• ATP-binding cassette sub-family A member 4
• ATP-binding cassette transporter, retinal-specific
• ATP-binding cassette, sub-family A (ABC1), member 4
• ATP-binding transporter, retina-specific
• CORD3
• EC 3.6.3
• FFMFLJ17534
• photoreceptor rim protein
• retinal-specific ATP-binding cassette transporter
• retina-specific ABC transporter
• RIM ABC transporter
• RIM protein
• RmP
• RP19
• Stargardt disease protein
• STGD
• STGD1

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ABCA4 Antibody (NB100-93468)(1)

Publication using NB100-93468

• Singh HP, Jalali S, Hejtmancik JF, Kannabiran C Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy Am J Ophthalmol 2006-05-01 [PMID: 16546111]

Bioinformatics

• Gene Symbol: ABCA4
• Entrez:
  • 24(Human)
• Uniprot:
  • NP_000341.2(Human)