4-1BB Ligand/TNFSF9 Antibody Summary
Recombinant fragment corresponding to a region within amino acids 49 and 254 of TNFSF9 (Uniprot ID#P41273)
Membrane; Single-pass type II membrane protein
Immunogen affinity purified
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Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7).
Immunogen affinity purified
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Alternate Names for 4-1BB Ligand/TNFSF9 Antibody
- 41BB Ligand
- 4-1BB ligand
- homolog of mouse 4-1BB-L
- receptor 4-1BB ligand
- tumor necrosis factor (ligand) superfamily, member 9
- tumor necrosis factor ligand superfamily member 9
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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