4-1BB Ligand/TNFSF9 Products

Description

CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen over stimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.

Bioinformatics

Entrez	21950 Mouse 8744 Human
Uniprot	NM_003811 Human NP_003802 Human P41273 Human P41274 Mouse
Product By Gene ID	8744
Alternate Names	4-1BB ligand 4-1BBL 4-1BB-L CD137L homolog of mouse 4-1BB-L receptor 4-1BB ligand tumor necrosis factor (ligand) superfamily, member 9 tumor necrosis factor ligand superfamily member 9

Research Areas for 4-1BB Ligand/TNFSF9

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Apoptosis