17 beta-HSD1/HSD17B1 Antibody (860020) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 860020
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

17 beta-HSD1/HSD17B1 Antibody (860020) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human 17 beta ‑HSD1/HSD17B1
  Ala2-Gln328
  Accession # P14061
• Specificity: Detects human 17 beta ‑HSD1/HSD17B1 in ELISAs.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for 17 beta-HSD1/HSD17B1 Antibody (860020) [Alexa Fluor® 647]

• 17 betaHSD1
• 17 beta-HSD1
• 17-beta-HSD 1
• 17-beta-hydroxysteroid dehydrogenase type 1
• 20 alpha-hydroxysteroid dehydrogenase
• 20-alpha-HSD
• E17KSR
• E2DH
• EC 1.1.1.62
• EDH17B1
• EDH17B2
• EDH17B2EDHB17
• EDHB17
• estradiol 17-beta-dehydrogenase 1
• estradiol 17-beta-dehydrogenase-1
• HSD17
• HSD17B1
• hydroxysteroid (17-beta) dehydrogenase 1 isoform
• hydroxysteroid (17-beta) dehydrogenase 1
• MGC138140
• Placental 17-beta-hydroxysteroid dehydrogenase
• SDR28C1
• short chain dehydrogenase/reductase family 28CE, member 1

Background

HSD17B1 (Hydroxysteroid 17-beta dehydrogenase type 1; also 17  beta ‑HSD1 and E2DH) is a 33-34 kDa member of the short chain dehydrogenase/reductase (SDR) superfamily of molecules. It is a cytoplasmic breast, placental and gonadal enzyme that both converts DHEA to estrogen A-diol, and inactivates DHT through oxidation and reduction. Human HSD17B1 is 328 amino acids (aa) in length. It contains an NADP binding site (aa 10-38) and a steroid catalytic site (aa 210-221). HSD17B1 functions as a 68 kDa noncovalently-linked homodimer. Over aa 2-328, human HSD17B1 shares 65% aa identity with mouse HSD17B1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • P14061(Human)