17 beta-HSD1/HSD17B1 Products

Antibodies
17 beta-HSD1/HSD17B1 Antibody ...
17 beta-HSD1/HSD17B1 Antibody (2E5)
H00003292-M03
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
17 beta-HSD1/HSD17B1 Antibody ...
17 beta-HSD1/HSD17B1 Antibody (860...
MAB7178
Species: Hu
Applications: WB, Simple Western
Host: Mouse Monoclonal
17 beta-HSD1/HSD17B1 Antibody ...
17 beta-HSD1/HSD17B1 Antibody
AF7178
Species: Hu
Applications: WB
Host: Sheep Polyclonal
Proteins
17 beta-HSD1/HSD17B1 Recombin ...
17 beta-HSD1/HSD17B1 Recombinant P...
NBP2-39053PEP
Species: Hu
Applications: AC
17 beta-HSD1/HSD17B1 Recombin ...
17 beta-HSD1/HSD17B1 Recombinant P...
NBP1-84901PEP
Species: Hu
Applications: AC
17 beta-HSD1/HSD17B1 Recombin ...
17 beta-HSD1/HSD17B1 Recombinant P...
NBP2-23127
Species: Hu
Applications: PAGE
RNAi
17 beta-HSD1/HSD17B1 RNAi
17 beta-HSD1/HSD17B1 RNAi
H00003292-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4)

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Product By Gene ID 3292
Alternate Names
  • 20-alpha-HSD
  • EDH17B1
  • 20 alpha-hydroxysteroid dehydrogenase
  • EC 1.1.1.62
  • 17-beta-hydroxysteroid dehydrogenase type 1
  • E17KSR
  • 17-beta-HSD 1
  • short chain dehydrogenase/reductase family 28CE, member 1
  • Placental 17-beta-hydroxysteroid dehydrogenase
  • hydroxysteroid (17-beta) dehydrogenase 1 isoform
  • SDR28C1
  • estradiol 17-beta-dehydrogenase-1
  • MGC138140
  • estradiol 17-beta-dehydrogenase 1
  • HSD17
  • EDH17B2EDHB17
  • E2DH
  • hydroxysteroid (17-beta) dehydrogenase 1

Research Areas for 17 beta-HSD1/HSD17B1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer

PTMs for 17 beta-HSD1/HSD17B1

Learn more about PTMs related to 17 beta-HSD1/HSD17B1.

Cleavage
Methylation
Demethylation
Phosphorylation
Reduction
Hydroxylation
Glycosylation

Bioinformatics Tool for 17 beta-HSD1/HSD17B1

Discover related pathways, diseases and genes to 17 beta-HSD1/HSD17B1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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