17 beta-HSD1/HSD17B1 Products

Description

The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4)

Bioinformatics

Entrez	15485 Mouse 25116 Rat 3292 Human
Uniprot	NP_000404 Human P14061 Human
Product By Gene ID	3292
Alternate Names	17-beta-HSD 1 17-beta-hydroxysteroid dehydrogenase type 1 20 alpha-hydroxysteroid dehydrogenase 20-alpha-HSD E17KSR E2DH EC 1.1.1.62 EDH17B1 EDH17B2EDHB17 estradiol 17-beta-dehydrogenase 1 estradiol 17-beta-dehydrogenase-1 HSD17 hydroxysteroid (17-beta) dehydrogenase 1 isoform hydroxysteroid (17-beta) dehydrogenase 1 MGC138140 Placental 17-beta-hydroxysteroid dehydrogenase SDR28C1 short chain dehydrogenase/reductase family 28CE, member 1

Research Areas for 17 beta-HSD1/HSD17B1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer