Killing two birds with one stone: Treating inflammation and cancer by inhibiting prolyl-4-hydroxylase-1

Getting Physical: Link between Lipid Metabolism and Hypoxia Target Genes

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

HIF-1 alpha and HIF-2 alpha in Muscle Development

HIF-2 alpha, Tumor Suppression and Cell Survival

HIF-2 alpha is one subunit within the HIF-2 nuclear protein that regulates cellular responses to hypoxia (low oxygen tension conditions). Hydroxylation post-translational modifications on particular HIF residues target them for degradation. Luo, et al.

HIF Prolyl Hydroxylase 1: A Key Regulator of HIF1A Levels

Hypoxia inducible factors (HIFs) are transcription factors that regulate the cellular response to decreases in oxygen levels. Under conditions of hypoxia HIFs activate the transcription of a diverse range of genes, resulting in increased oxygen delivery to the cell or metabolic adaptation.