DRP1 Antibody

DRP1 (dynamin-related protein 1) is a highly conserved large GTPase protein which is involved in several important structural features of mitochondria, including mitochondrial shape, size, distribution, remodeling and maintenance. It functions in mitochondrial as well as peroxisomal division, and facilitates membrane fission via oligomerization into ring-like structures that wrap around fission site to constrict/split the membranes through a GTP hydrolysis-dependent mechanism. For normal brain development, DRP1 plays an essential role by mediating developmentally-regulated apoptosis during neural tube development. It is also required for a normal rate of cytochrome c release or caspase activation during apoptosis and for mitochondrial fission during mitosis, programmed necrosis execution and also for vesicle transport. Moreover, it is associated with mitochondrial structural and functional alterations such as fragmentation, phosphorylation, SUMOylation, ubiquitination and cell death. Drp1 interacts with amyloid beta, causing abnormal mitochondrial dynamics and neuronal damage in Alzheimer's disease patients, and defective DRP1 is also linked to encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IP, WB.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using NB110-55237	Applications	Species
Zhao Q, Liu Z, Song P et al. Mitochondria Derived Vesicle Packaging as a Novel Therapeutic Mechanism in Pulmonary Hypertension American journal of respiratory cell and molecular biology 2023-09-15 [PMID: 37713305]
Dufour D, Dumontet T, Sahut-Barnola I et al. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation Research Square 2022-03-18 [PMID: 36543805] (WB, Mouse)	WB	Mouse
McAlinden KD, Naidu V, Sohal SS, Sharma P In utero Exposure to Nicotine Containing Electronic Cigarettes Increases the Risk of Allergic Asthma in Female Offspring Am. J. Physiol. Lung Cell Mol. Physiol. 2020-08-12 [PMID: 32783625]
Li G, Chan Y. L, et al. E-cigarettes damage the liver and alter nutrient metabolism in pregnant mice and their offspring. Ann N Y Acad Sci 2020-09-01 [PMID: 32557680]
Li G, Chan Y. L, et al. A Mitochondrial Specific Antioxidant Reverses Metabolic Dysfunction and Fatty Liver Induced by Maternal Cigarette Smoke in Mice. Nutrients 2019-07-21 [PMID: 31330878]
Zou P, Liu L, Zheng LD et al. Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment Oxid Med Cell Longev 2016-09-01 [PMID: 27746856] (IF/IHC, Human)	IF/IHC	Human
Chen SD, Zhen YY, Lin JW et al. Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus CNS Neurosci Ther 2016-08-31 [PMID: 27577016] (WB, Human)	WB	Human
Ishizu N, Yui D, Hebisawa A et al. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice. Hum Mol Genet 2016-08-25 [PMID: 27562021] (WB, Mouse)	WB	Mouse
Fu J, Yu Hm, Chiu Sy et al. Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated neurodegeneration. PLoS Genet. 2014-10-01 [PMID: 25299344] (IF/IHC, IP, WB, Mouse)	IF/IHC, IP, WB	Mouse
Montaigne D, Marechal X, Coisne A et al. Myocardial Contractile Dysfunction is Associated with Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but not in Obese Patients. Circulation. 2014-06-13 [PMID: 24928681] (WB, Human)	WB	Human
Stavru F, Palmer AE, Wang C et al. Atypical mitochondrial fission upon bacterial infection. Proc Natl Acad Sci U S A. 2013-10-01 [PMID: 24043775] (ICC/IF, Human)	ICC/IF	Human
Wappler EA, Institoris A, Dutta S et al. Mitochondrial Dynamics Associated with Oxygen-Glucose Deprivation in Rat Primary Neuronal Cultures. PLoS One 2013-05-02 [PMID: 23658809] (WB, Rat)	WB	Rat
Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL. Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res;110(11):1484-97. 2012-05-25 [PMID: 22511751] (WB, IF/IHC, ICC/IF, Human)	WB, IF/IHC, ICC/IF	Human
Manczak M, Sesaki H, Kageyama Y, Reddy PH. Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies Biochim Biophys Acta 2012-02-23 [PMID: 22387883] (WB, Mouse)	WB	Mouse
Rehman J, Zhang HJ, Toth PT, Zhang Y, Marsboom G, Hong Z, Salgia R, Husain AN, Wietholt C, Archer SL. Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. FASEB J;26(5):2175-86. 2012-05-01 [PMID: 22321727] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Calkins M, Manczak M, Mao P et al. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer’s disease. Hum Mol Genet. 2011-08-25 [PMID: 21873260]
Courchesne SL, Karch C, Pazyra-Murphy MF, Segal RA. Sensory Neuropathy Attributable to Loss of Bcl-w. J. Neurosci. 31(5):1624-1634. 2011-02-02 [PMID: 21289171] (WB, Mouse)	WB	Mouse
Thomas M, Felcht M, Kruse K et al. Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. J Biol Chem 2010-07-30 [PMID: 20519501] (Human)		Human
Cheng Z, Guo S, Copps K et al. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med;15(11):1307-11. 2009-11-01 [PMID: 19838201] (WB, Mouse)	WB	Mouse
Show All 19 Publications. Collapse Publications.

Array NB110-55237

• DRP1 Antibodies
• DRP1 Lysates
• DRP1 Proteins