DRP1 Products

Description

DRP1 (dynamin-related protein 1) is a highly conserved large GTPase protein which is involved in several important structural features of mitochondria, including mitochondrial shape, size, distribution, remodeling and maintenance. It functions in mitochondrial as well as peroxisomal division, and facilitates membrane fission via oligomerization into ring-like structures that wrap around fission site to constrict/split the membranes through a GTP hydrolysis-dependent mechanism. For normal brain development, DRP1 plays an essential role by mediating developmentally-regulated apoptosis during neural tube development. It is also required for a normal rate of cytochrome c release or caspase activation during apoptosis and for mitochondrial fission during mitosis, programmed necrosis execution and also for vesicle transport. Moreover, it is associated with mitochondrial structural and functional alterations such as fragmentation, phosphorylation, SUMOylation, ubiquitination and cell death. Drp1 interacts with amyloid beta, causing abnormal mitochondrial dynamics and neuronal damage in Alzheimer's disease patients, and defective DRP1 is also linked to encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF).

Bioinformatics

Product By Gene ID	10059
Alternate Names	DLP1 DNM1L DRP1 DRP1Dnm1p/Vps1p-like protein DVLP DVLPEC 3.6.5.5 Dymple DYMPLEDYNIV-11 dynamin 1-like Dynamin family member proline-rich carboxyl-terminal domain less dynamin-1-like protein Dynamin-like protein 4 Dynamin-like protein IV Dynamin-like protein Dynamin-related protein 1 FLJ41912 HdynIV VPS1

Research Areas for DRP1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology
Mitochondrial Fusion Proteins
Neurodegeneration
Neuroscience
Signal Transduction

Related DRP1 Blog Posts

Check out the latest blog posts on DRP1.

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress By Jamshed Arslan, Pharm. D., PhD. December 1 is the World AIDS Day. Despite the combination antiretroviral therapy, 10-25% of Human Immunodeficiency Virus (HIV)-positive individuals report neurocognitive impairm...    Read more.

Understanding Mitophagy Mechanisms: Canonical PINK1/Parkin, LC3-Dependent Piecemeal, and LC3-Independent Mitochondrial Derived Vesicles By Christina Towers, PhD What is Mitophagy?The selective degradation of mitochondria via double membrane autophagosome vesicles is called mitophagy. Damaged mitochondria can generate harmful amounts of reactive ox...    Read more.

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease  By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...    Read more.

Dynamin-related Protein 1 (DRP1) in Mitochondria and Apoptosis. Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mech...    Read more.

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