Dynamin-related Protein 1 (DRP1) in Mitochondria and Apoptosis.

Mon, 09/24/2012 - 09:14

Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mechanism. DRP1 also facilitates developmentally-regulated apoptosis during neural tube development and is required for the normal rate of cytochrome c release for caspase activation during apoptosis (1).

Immunohistochemistry: DRP1 antibody [NB110-55237] - IHC staining of renal tubular epithelium and visceral epithelial cells of glomeruli in Human kidney cortex. 40X magnification. Immunohistochemistry: DRP1 antibody NB110-55237

Down regulation of DRP1 using siRNA and subsequent detection using anti-DRP1 antibodies in various cell lines led to inhibition of the fission machinery in Bax/Bak-mediated apoptosis, by preventing the fragmentation of the mitochondrial network and partially inhibiting the release of cytochrome c from the mitochondria. These observations suggest that the fission of mitochondria is a dispensable event in Bax/Bak-dependent apoptosis influenced by DRP1 (2). The specific Bax/Bak-dependent biochemical transitions in DRP1 properties link the induction of cell death to the changes in mitochondrial membrane dynamics demonstrate that the apoptotic machinery regulates the biochemical properties of DRP1 during cell death (3). Novus Biologicals offers an extensive collection of research tools in the form of siRNA, cell lysates and DRP1 antibodies for your research needs.

  1. PMID: 17015472
  2. PMID: 17015472
  3. PMID: 17470634


Novus Biologicals offers DRP1 reagents for your research needs including:




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